Environmental enteric dysfunction is associated with carnitine deficiency and altered fatty acid oxidation

RD Semba, I Trehan, X Li, R Moaddel, MI Ordiz… - …, 2017 - thelancet.com
Background Environmental enteric dysfunction (EED), a condition characterized by small
intestine inflammation and abnormal gut permeability, is widespread in children in …

Metabolic alterations in children with environmental enteric dysfunction

RD Semba, M Shardell, I Trehan, R Moaddel… - Scientific reports, 2016 - nature.com
Environmental enteric dysfunction, an asymptomatic condition characterized by
inflammation of the small bowel mucosa, villous atrophy, malabsorption, and increased …

Environmental enteric dysfunction is associated with altered bile acid metabolism

RD Semba, M Gonzalez-Freire… - Journal of pediatric …, 2017 - journals.lww.com
Objectives: Environmental enteric dysfunction (EED), a clinically asymptomatic condition
characterized by inflammation of the small bowel mucosa, villous atrophy, and increased gut …

Biomarkers of environmental enteric dysfunction among children in rural Bangladesh

RK Campbell, KJ Schulze, S Shaikh… - Journal of pediatric …, 2017 - journals.lww.com
Objectives: Environmental enteric dysfunction (EED) may inhibit growth and development in
low-and middle-income countries, but available assessment methodologies limit its study. In …

Markers of environmental enteric dysfunction are associated with neurodevelopmental outcomes in Tanzanian children

AJ Etheredge, K Manji, M Kellogg, H Tran… - Journal of pediatric …, 2018 - journals.lww.com
Background: Chronic exposure to enteropathogens may result in environmental enteric
dysfunction (EED), a subclinical condition associated with poor child growth. Growth …

[HTML][HTML] Mucosal genomics implicate lymphocyte activation and lipid metabolism in refractory environmental enteric dysfunction

Y Haberman, NT Iqbal, S Ghandikota… - Gastroenterology, 2021 - Elsevier
Background & Aims Environmental enteric dysfunction (EED) limits the Sustainable
Development Goals of improved childhood growth and survival. We applied mucosal …

Improving the detection of environmental enteric dysfunction: a lactulose, rhamnose assay of intestinal permeability in children aged under 5 years exposed to poor …

WA Faubion, M Camilleri, JA Murray, P Kelly… - BMJ global …, 2016 - gh.bmj.com
Background Environmental enteric dysfunction (EED) is an asymptomatic intestinal disorder
affecting populations living in conditions of poor sanitation and hygiene. The study tested …

[HTML][HTML] Bile acid profiling reveals distinct signatures in undernourished children with environmental enteric dysfunction

X Zhao, KDR Setchell, R Huang, I Mallawaarachchi… - The Journal of …, 2021 - Elsevier
Background Intestinal inflammation and malabsorption in environmental enteric dysfunction
(EED) are associated with early childhood growth faltering in impoverished settings …

Putative biomarkers of environmental enteric disease fail to correlate in a cross-sectional study in two study sites in sub-Saharan Africa

P Vonaesch, M Winkel, N Kapel, A Nestoret… - Nutrients, 2022 - mdpi.com
Environmental enteric dysfunction (EED) is an elusive, inflammatory syndrome of the small
intestine thought to be associated with enterocyte loss and gut leakiness and lead to stunted …

[HTML][HTML] Environmental enteric dysfunction: a case definition for intervention trials

DM Denno, PI Tarr, JP Nataro - The American journal of tropical …, 2017 - ncbi.nlm.nih.gov
Environmental Enteric Dysfunction (EED) was first described as a malabsorption syndrome
with small intestinal villous flattening among healthy adults in Thailand and other low …