Wiring the nervous system relies on the interplay of intrinsic and extrinsic signaling
molecules that control neurite extension, neuronal polarity, process maturation and …

Embryogenesis is a highly regulated process in which the precise spatial and temporal
release of soluble cues directs differentiation of multipotent stem cells into discrete …

Understanding the signals that guide neuronal development and direct formation of axons,
dendrites, and synapses during wiring of the brain is a fundamental challenge in …

Chemical and topographical cues can be used to guide dissociated neurons into user-
defined network geometries on artificial substrates, yet control of neuron polarity …

Substrate-bound gradients expressed in numerous spatio-temporal patterns play a crucial
role during the development of complex neural circuits. A deeper understanding of the axon …

Assembly of functional neural circuits relies on the ability of axons to navigate a complex
landscape of guidance cues in the extracellular environment. In this report, we investigate …

The ability to pattern multiple bioactive cues on a surface is valuable for understanding how
neurons interact with their complex extracellular environment. In this report, we introduce a …

By locally dispensing poly-l-lysine (PLL) molecules with a FluidFM onto a protein and cell
resistant poly-l-lysine-graft-polyethylene glycol (PLL-g-PEG) coated substrate, the …

We employ simple geometrical rules to design a set of nanotopographies able to interfere
with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint …

We explore textural cues as a mechanism for controlling neuronal process outgrowth in
primary cultures of mammalian neurons. The work uses a form of decal transfer lithography …