Hemorrhagic cystitis is a common complication in children receiving cyclophosphamide, a
chemotherapeutic alkylating agent. Acrolein is a urinary metabolite from cyclophosphamide …

AIM: Acrolein (ACR) is a urinary metabolite of cyclophosphamide (CPS) and ifosfamide
(IFS), which has been demonstrated to be the causative agent of hemorrhagic cystitis (HC) …

Purpose: We evaluated the relationship between nitric oxide and hyperbaric oxygenation in
the pathogenesis and treatment of cyclophosphamide induced hemorrhagic cystitis in rats …

PURPOSE: The role of substance P, inducible nitric oxide synthase, and cyclooxygenase-1
and 2 on the pathogenesis of cyclophosphamide induced cystitis was investigated in rats …

Cyclophosphamide (CP) is an antineoplastic agent used alone or in combination with other
chemotherapeutic agents for the treatment of many neoplastic diseases. Hemorrhagic …

Cyclophosphamide is one of the most prescribed antineoplastic agents. Hemorrhagic cystitis
is one of the most common side effects of cyclophosphamide. Captopril is usually used as …

Purpose: We investigated the participation of nitric oxide in ifosfamide induced hemorrhagic
cystitis in mice, and the involvement of tumor necrosis factor (TNF)-α and interleukin (IL)-1β …

Purpose Ifosfamide (IFS) is often involved in the occurrence of hemorrhagic cystitis due to
direct contact of its metabolite acrolein with uroepithelium. It has been shown that COX-2 is …

OBJECTIVE To investigate the protective roles of type 4 phosphodiesterase (PDE4) inhibitor
in cyclophosphamide (CYP)‐induced haemorrhagic cystitis, as the PDE4 inhibitor has anti …

Purpose: It was previously shown that nitric oxide (NO) produced by inducible NO synthase
(iNOS) is responsible for cyclophosphamide (CP) induced cystitis. In this study we evaluated …