The technology for generation of induced pluripotent stem cells (iPSCs) has made
significant contributions to various scientific fields, and the field of cancer biology is no …

Cancers are heterogeneous, multicellular societies that constitute solid tumors which
comprise the neoplastic progenies of the tumor-initiating cell and the progenies of …

While functional heterogeneity of fibroblastic cells populating the tumor microenvironment is
increasingly recognized, lack of definitive markers complicates elucidation of roles among …

Correction: Cancer-associated fibroblasts: overview, progress, challenges, and directions Page 1
Cancer Gene Therapy (2021) 28:1074 https://doi.org/10.1038/s41417-021-00343-3 …

The demonstration of induced pluripotency and direct lineage conversion has led to
remarkable insights regarding the roles of transcription factors and chromatin regulators in …

Tumors become invasive by penetrating adjacent connective tissue, but the underlying
biological mechanisms remain obscure. We recently identified a precise gene expression …

Fibroblasts typically are mesenchymal-lineage cells that produce collagen and other
extracellular matrix molecules to provide structural support for normal tissues [1]. As part of …

Differentiation features in cancer cells are typically attributed to the cell of origin. In this issue
of Cancer Cell, Drummond et al. demonstrate a transdifferentiation program apparent in …

Cell states can give tumorigenesis a head start | Nature Reviews Cancer Skip to main content
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