Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report
molecular profiling of 230 resected lung adenocarcinomas using messenger RNA …

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report
molecular profiling of 230 resected lung adenocarcinomas using messenger RNA …

Determining the genetic basis of cancer requires comprehensive analyses of large
collections of histopathologically well-classified primary tumours. Here we report the results …

Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …

Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is
responsible for more than 500,000 deaths per year worldwide. Here, we report exome and …

Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the
p110-α catalytic subunit (encoded by PIK3CA). They are most frequently observed in two …

In cancer, genetically activated proto-oncogenes often induce “upstream” dependency on
the activity of the mutant oncoprotein. Therapeutic inhibition of these activated oncoproteins …

All cancers harbor molecular alterations in their genomes. The transcriptional consequences
of these somatic mutations have not yet been comprehensively explored in lung cancer …

Standard cytotoxic chemotherapy is effective for some cancers, but for many others,
available treatments offer only a limited survival benefit. Lung adenocarcinoma is one such …

The phosphoinositide 3-kinase (PI3K) and RAS oncoproteins are activated in many major
tumor types and control linked signaling pathways. An inhibitor of PI3K is now shown to …