[HTML][HTML] Adenosine signaling in autoimmune disorders
The molecular components of the purinergic system (ie, receptors, metabolizing enzymes
and membrane transporters) are widely expressed in the cells of the immune system …
and membrane transporters) are widely expressed in the cells of the immune system …
[HTML][HTML] Dysregulation of adenosinergic signaling in systemic and organ-specific autoimmunity
Exact causes for autoimmune diseases remain unclear and no cures are available.
Breakdown of immunotolerance could set the stage for unfettered immune responses that …
Breakdown of immunotolerance could set the stage for unfettered immune responses that …
Adenosine: an endogenous modulator of innate immune system with therapeutic potential
V Kumar, A Sharma - European journal of pharmacology, 2009 - Elsevier
Adenosine is a purine nucleoside, which is produced inside the body under metabolic stress
like hypoxic conditions, acute or chronic inflammatory tissue insults. The synthesis of …
like hypoxic conditions, acute or chronic inflammatory tissue insults. The synthesis of …
The role of extracellular adenosine generation in the development of autoimmune diseases
Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune
responses by interacting with specific receptors expressed by immune effector cells. ADO is …
responses by interacting with specific receptors expressed by immune effector cells. ADO is …
The role of adenosine receptors in rheumatoid arthritis
Rheumatoid arthritis (RA), is the most common inflammatory musculoskeletal disease
inducing diminished quality-of-life in the affected individuals and having major impact on …
inducing diminished quality-of-life in the affected individuals and having major impact on …
Adenosine signaling and the immune system: When a lot could be too much
Adenosine is increasingly recognized as a key mediator of the immune response. Signals
delivered by extracellular adenosine are detected and transduced by G-protein-coupled cell …
delivered by extracellular adenosine are detected and transduced by G-protein-coupled cell …
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …
Adenosine deaminase in the modulation of immune system and its potential as a novel target for treatment of inflammatory disorders
The adenosine pathway is a powerful evolutionarily selected mechanism aimed at a fine
modulation of inflammatory responses and protection of tissues from injuries. Adenosine …
modulation of inflammatory responses and protection of tissues from injuries. Adenosine …
Adenosine receptors and inflammation
MR Blackburn, CO Vance, E Morschl… - Adenosine receptors in …, 2009 - Springer
Extracellular adenosine is produced in a coordinated manner from cells following cellular
challenge or tissue injury. Once produced, it serves as an autocrine-and paracrine-signaling …
challenge or tissue injury. Once produced, it serves as an autocrine-and paracrine-signaling …
Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
MJL Bours, ELR Swennen, F Di Virgilio… - Pharmacology & …, 2006 - Elsevier
Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …
The immune system is occupied with protecting the host against such dangers in order to …