Synergism has been used to obtain analgesia at doses at which side effects are minimal. In
addition, it has been demonstrated that inhibition of cyclooxygenase-2 is responsible for the …

Over the decades, nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids are the most
commonly used analgesics in the management of acute and chronic pain. In order to assess …

The analgesic effects of the intrathecal coadministration of morphine with nimesulide,
meloxicam and parecoxib, preferential cyclooxygenase-2 (COX-2) inhibitors, were studied in …

Background: Pain is a common problem, often associated with inflammatory conditions.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used as analgesic …

Studies with inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 inhibitor were
conducted to assess their synergistic antinociceptive effect and possible therapeutic …

The present study was aimed to assess the combined effects of cyclooxygenase and 5-
lipoxygenase (COX/5-LOX) inhibitors in different animal models of nociception. Naproxen …

Pain‐induced functional impairment in the rat (PIFIR) is a model of inflammatory and arthritic
pain similar to that of clinical gout. Nociception is induced by the intra‐articular injection of …

Non-steroidal antiinflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) enzyme
and so they are effective analgesic, antiinflammatory and antipyretic drugs. The discovery of …

Opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are used to relieve acute and
chronic pain. The purpose of this study was to determine the degree of interaction between …

The antinociception induced by the intrathecal coadministration of combinations of morphine
with the nonsteroidal anti-inflammatory drugs (NSAIDs) naproxen, piroxicam, metamizol …