[HTML][HTML] Is adult hippocampal neurogenesis really relevant for the treatment of psychiatric disorders?

M Carli, S Aringhieri, S Kolachalam… - Current …, 2021 - ncbi.nlm.nih.gov
Adult neurogenesis consists in the generation of newborn neurons from neural stem cells
taking place in the adult brain. In mammals, this process is limited to very few areas of the …

[HTML][HTML] Adult hippocampal neurogenesis and affective disorders: New neurons for psychic well-being

W Gomes-Leal - Frontiers in Neuroscience, 2021 - frontiersin.org
A paradigm shift in neuroscience was the discovery that new neurons are constantly
produced in the adult mammalian brain of several species, including Homo sapiens. These …

Adult neurogenesis and neural stem cells as a model for the discovery and development of novel drugs

P Taupin - Expert Opinion on Drug Discovery, 2010 - Taylor & Francis
Neurogenesis occurs in discrete regions of the adult brain, particularly the hippocampus. It is
enhanced in the hippocampus of animal models and patients with neurological diseases …

Functional role of adult hippocampal neurogenesis as a therapeutic strategy for mental disorders

H Jun, S Mohammed Qasim Hussaini… - Neural …, 2012 - Wiley Online Library
Adult neurogenesis, the process of generating new neurons from neural stem cells, plays
significant roles in synaptic plasticity, memory, and mood regulation. In the mammalian …

To be or not to be: adult neurogenesis and psychiatry

AJ Eisch, EJ Nestler - Clinical Neuroscience Research, 2002 - Elsevier
The recent discovery that neurons are born throughout life in specific brain regions has
caused explosive interest in the possible involvement of adult neurogenesis in a host of …

Neurogenesis in the adult brain: from bench to bedside?

MD Brandt, A Storch - Fortschritte der Neurologie-psychiatrie, 2008 - europepmc.org
Two regions of the mammalian brain maintain the capability to generate new neurons
throughout lifetime: Neuronal stem-and precursor cells proliferate in the subgranulare zone …

Research update: neurogenesis in adult brain and neuropsychiatric disorders.

GA Elder, R De Gasperi… - Mount Sinai Journal of …, 2006 - search.ebscohost.com
Until recently neurogenesis in mammals was considered to occur only during the embryonic
and early post-natal periods and to have no significant role in the adult nervous system …

Hippocampal neurogenesis: a matter of survival

DC Lagace, MA Noonan… - American Journal of …, 2007 - Am Psychiatric Assoc
The hippocampus has long been known to play a prominent role in establishing new
memories. More recently, the hippocampus has been implicated in several psychiatric …

Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluation

NA DeCarolis, AJ Eisch - Neuropharmacology, 2010 - Elsevier
Over one-quarter of adult Americans are diagnosed with a mental illness like Major
Depressive Disorder (MDD), Post-Traumatic Stress Disorder (PTSD), schizophrenia, and …

Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders

DJ David, J Wang, BA Samuels, Q Rainer… - The …, 2010 - journals.sagepub.com
Adult neurogenesis in the dentate gyrus of the hippocampus has gained considerable
attention as a cellular substrate for both the pathophysiology and treatment of depression …