Modulated expression of specific tRNAs drives gene expression and cancer progression
Transfer RNAs (tRNAs) are primarily viewed as static contributors to gene expression. By
developing a high-throughput tRNA profiling method, we find that specific tRNAs are …
developing a high-throughput tRNA profiling method, we find that specific tRNAs are …
Transfer RNAs as dynamic and critical regulators of cancer progression
AM Pinzaru, SF Tavazoie - Nature Reviews Cancer, 2023 - nature.com
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …
tRNA dysregulation and disease
EA Orellana, E Siegal, RI Gregory - Nature Reviews Genetics, 2022 - nature.com
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
Two isoleucyl tRNAs that decode synonymous codons divergently regulate breast cancer metastatic growth by controlling translation of proliferation-regulating genes
The human genome contains 61 codons encoding 20 amino acids. Synonymous codons
representing a given amino acid are decoded by a set of transfer RNAs (tRNAs) called …
representing a given amino acid are decoded by a set of transfer RNAs (tRNAs) called …
Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
Transfer RNAs (tRNA) are quintessential in deciphering the genetic code; disseminating
nucleic acid triplets into correct amino acid identity. While this decoding function is clear, an …
nucleic acid triplets into correct amino acid identity. While this decoding function is clear, an …
Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells
M Pavon-Eternod, S Gomes, MR Rosner, T Pan - Rna, 2013 - rnajournal.cshlp.org
Transfer RNAs (tRNAs) are typically considered housekeeping products with little regulatory
function. However, several studies over the past 10 years have linked tRNA misregulation to …
function. However, several studies over the past 10 years have linked tRNA misregulation to …
Repertoires of tRNAs: the couplers of genomics and proteomics
The pool of transfer RNA (tRNA) molecules in cells allows the ribosome to decode genetic
information. This repertoire of molecular decoders is positioned in the crossroad of the …
information. This repertoire of molecular decoders is positioned in the crossroad of the …
tRNA modifications: insights into their role in human cancers
Y Wang, EW Tao, J Tan, QY Gao, YX Chen… - Trends in Cell Biology, 2023 - cell.com
Transfer RNA (tRNA) plays a central role in translation by functioning as a biological link
between messenger RNA (mRNA) and proteins. One prominent feature of the tRNA …
between messenger RNA (mRNA) and proteins. One prominent feature of the tRNA …
Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers
The protein translational system, including transfer RNAs (tRNAs) and several categories of
enzymes, plays a key role in regulating cell proliferation. Translation dysregulation also …
enzymes, plays a key role in regulating cell proliferation. Translation dysregulation also …
Emerging roles of tRNA in adaptive translation, signalling dynamics and disease
S Kirchner, Z Ignatova - Nature Reviews Genetics, 2015 - nature.com
Abstract tRNAs, nexus molecules between mRNAs and proteins, have a central role in
translation. Recent discoveries have revealed unprecedented complexity of tRNA …
translation. Recent discoveries have revealed unprecedented complexity of tRNA …