Lactating rat mammary gland expresses a deiodinating activity that, on the basis of kinetic
characteristics, corresponds to the so-called 5′-deiodinase type I (D1). In the present study …

The type II iodothyronine deiodinase (D2) catalyzes the 5′-deiodination of thyroxine to
yield the biologically active form, 3, 3′, 5,-tri-iodothyronine, and is a member of the …

In the present study we have obtained several lines of evidence indicating the presence of
type II iodothyronine deiodinase (DII) in the mouse mammary gland. 5′-deiodinase activity …

Abstract Thyroxine 5′-deiodinase (5′ D) catalyses deiodination of the prohormone
thyroxine (T 4) to the metabolically active hormone 3, 5, 3′-tri-iodothyronine (T 3) …

Iodothyronine deiodinases III and II (D3 and D2) specific enzyme activities in human
placenta both decrease with gestational age. The relation of the enzyme activities with their …

抄録< jats: p> Thyroid hormone is essential for the normal function of virtually all tissues. The
iodothyronine deiodinases catalyze the removal of an iodine residue from the pro-hormone …

Abstract Type 2 deiodinase (D2) is a selenoenzyme catalyzing the activation of T4 to T3. D2
activity/mRNA ratios are often low, suggesting that there is significant posttranscriptional …

Thyroid hormones are of considerable importance for vertebrate reproductive function and
during development. To further assess the role of these compounds in this capacity, we …

Conversion of the prohormone T4 to the active hormone T3 is catalyzed by 5′-deiodinases,
enzymes that have not been purified. Previous studies have shown that modulating thyroid …

The type I iodothyronine deiodinase (D1) catalyzes the activation of T4 to T3 as well as the
degradation of T3 (rT3) and sulfated iodothyronines. A comparison of the catalytic activities …