DNA methylation epigenotypes in breast cancer molecular subtypes
NG Bediaga, A Acha-Sagredo, I Guerra, A Viguri… - Breast cancer …, 2010 - Springer
Introduction Identification of gene expression-based breast cancer subtypes is considered a
critical means of prognostication. Genetic mutations along with epigenetic alterations …
critical means of prognostication. Genetic mutations along with epigenetic alterations …
DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival
Introduction Breast cancer is a heterogeneous disease, with several intrinsic subtypes
differing by hormone receptor (HR) status, molecular profiles, and prognosis. However, the …
differing by hormone receptor (HR) status, molecular profiles, and prognosis. However, the …
Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
K Holm, C Hegardt, J Staaf, J Vallon-Christersson… - Breast cancer …, 2010 - Springer
Introduction Five different molecular subtypes of breast cancer have been identified through
gene expression profiling. Each subtype has a characteristic expression pattern suggested …
gene expression profiling. Each subtype has a characteristic expression pattern suggested …
[HTML][HTML] Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic …
JA Rønneberg, T Fleischer, HK Solvang… - Molecular …, 2011 - Elsevier
Breast cancer is a heterogeneous disease that can be divided in subtypes based on
histology, gene expression profiles as well as differences in genomic aberrations. Distinct …
histology, gene expression profiles as well as differences in genomic aberrations. Distinct …
[HTML][HTML] A DNA methylation-based definition of biologically distinct breast cancer subtypes
In cancer, epigenetic states are deregulated and thought to be of significance in cancer
development and progression. We explored DNA methylation-based signatures in …
development and progression. We explored DNA methylation-based signatures in …
Specific breast cancer prognosis‐subtype distinctions based on DNA methylation patterns
S Zhang, Y Wang, Y Gu, J Zhu, C Ci, Z Guo… - Molecular …, 2018 - Wiley Online Library
Tumour heterogeneity is an obstacle to effective breast cancer diagnosis and therapy. DNA
methylation is an important regulator of gene expression, thus characterizing tumour …
methylation is an important regulator of gene expression, thus characterizing tumour …
[HTML][HTML] DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables
The diversity of breast cancers reflects variations in underlying biology and affects the
clinical implications for patients. Gene expression studies have identified five major …
clinical implications for patients. Gene expression studies have identified five major …
An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells
Background Aberrant DNA methylation is frequently observed in breast cancer. However,
the relationship between methylation patterns and the heterogeneity of breast cancer has …
the relationship between methylation patterns and the heterogeneity of breast cancer has …
Genome-wide methylotyping resolves breast cancer epigenetic heterogeneity and suggests novel therapeutic perspectives
AS Tanas, VO Sigin, AI Kalinkin, NV Litviakov… - …, 2019 - Taylor & Francis
Aim: To provide a breast cancer (BC) methylotype classification by genome-wide CpG
islands bisulfite DNA sequencing. Materials & methods: XmaI-reduced representation …
islands bisulfite DNA sequencing. Materials & methods: XmaI-reduced representation …
A seven-gene CpG-island methylation panel predicts breast cancer progression
Y Li, AA Melnikov, V Levenson, E Guerra, P Simeone… - BMC cancer, 2015 - Springer
Background DNA methylation regulates gene expression, through the inhibition/activation of
gene transcription of methylated/unmethylated genes. Hence, DNA methylation profiling can …
gene transcription of methylated/unmethylated genes. Hence, DNA methylation profiling can …