Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

Plasmodium falciparum imposes an enormous burden upon the developing world, with 300
to 500 million cases and 1 to 2 million deaths per year (94). Despite extensive research …

Background Parasites causing severe malaria in non-immune patients express a restricted
subset of variant surface antigens (VSA), which are better recognized by immune sera than …

Background Variant surface antigens (VSA) exposed on the membrane of Plasmodium
falciparum infected erythrocytes mediate immune evasion and are important pathogenicity …

Disease severity in Plasmodium falciparum infections is a direct consequence of the
parasite's efficient evasion of the defense mechanisms of the human host. To date, one …

Modifications of the Plasmodium falciparum–infected red blood cell (iRBC) surface have
been linked to parasite-associated pathology. Such modifications enable the parasite to …

Intraerythrocytic Plasmodium falciparum exports proteins to the cytosol and to the plasma
membrane of the host cell. We here present data revealing the existence of a unique …

Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …

The var gene family encodes Plasmodium falciparum erythrocyte membrane 1 (PfEMP1)
proteins that act as virulence factors responsible for both antigenic variation and …

An immunovariant adhesion protein family in Plasmodium falciparum named erythrocyte
membrane protein 1 (PfEMP1), encoded by var genes, is responsible for both antigenic …