A proteomic analysis of the early secondary molecular effects caused by Cn2 scorpion toxin on neuroblastoma cells

MP Escalona, CVF Batista, RR Cassulini, MS Rios… - Journal of …, 2014 - Elsevier
Although the primary physiological effects produced by scorpion toxins are already well
known, most of the secondary molecular events following scorpion neurotoxins–ion channel …

Activation of sodium channel by a novel α-scorpion toxin, BmK NT2, stimulates ERK1/2 and CERB phosphorylation through a Ca2+ dependent pathway in neocortical …

X Zou, Y Wu, J Chen, F Zhao, F Zhang, B Yu… - International Journal of …, 2017 - Elsevier
Neuronal excitability controls the expression of a variety of genes and proteins and therefore
regulates neurite outgrowth and synapse formation, fundamental physiological processes …

Activation of sodium channels by α-scorpion toxin, BmK NT1, produced neurotoxicity in cerebellar granule cells: an association with intracellular Ca2+ overloading

Y He, X Zou, X Li, J Chen, L Jin, F Zhang, B Yu… - Archives of …, 2017 - Springer
Voltage-gated sodium channels (VGSCs) are responsible for the action potential generation
in excitable cells including neurons and involved in many physiological and pathological …

NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical β‐toxin sequence but with α‐like physiological activity

F del Río‐Portilla, E Hernández‐Marín… - European journal of …, 2004 - Wiley Online Library
Cn12 isolated from the venom of the scorpion Centruroides noxius has 67 amino‐acid
residues, closely packed with four disulfide bridges. Its primary structure and disulfide …

[PDF][PDF] Independent origins of scorpion toxins affecting potassium and sodium channels

S Zhang, B Gao, S Zhu - 2018 - ir.ioz.ac.cn
In recent years, the field of toxinology has expanded substantially. On the one hand it
studies venomous animals, plants and micro organisms in detail to understand their mode of …

Electrophysiological characterization of BmK I, an α-like scorpion toxin, on rNav1. 5 expressed in HEK293t cells

XH Feng, JX Chen, Y Liu, YH Ji - Toxicology in Vitro, 2008 - Elsevier
A recent study described the pharmacological properties of BmK I, an α-like toxin from the
Chinese scorpion Buthus martensi Karsch, on the cardiac sodium channel (hH1) expressed …

Evidence for the existence of a common ancestor of scorpion toxins affecting ion channels

C Zhijian, W Yingliang, S Jiqun… - … of biochemical and …, 2003 - Wiley Online Library
All scorpion toxins from different 30 species are simply reviewed. A new classification
system of scorpion toxins is first proposed: scorpion toxins are classified into three families …

Identification of structural elements of a scorpion α-neurotoxin important for receptor site recognition

N Zilberberg, O Froy, E Loret, S Cestele, D Arad… - Journal of Biological …, 1997 - ASBMB
α-Neurotoxins from scorpion venoms constitute the most studied group of modifiers of the
voltage-sensitive sodium channels, and yet, their toxic site has not been characterized. We …

Scorpion toxins to unravel the conundrum of ion channel structure and functioning

E Ortiz, LD Possani - Toxicon, 2018 - Elsevier
The consequences of scorpion stings on the affected victims, including humans, have been
known since ancient times. The effects of the venom, first on neurotransmission and …

Isolation, characterization and comparison of a novel crustacean toxin with a mammalian toxin from the venom of the scorpion Centruroides noxius Hoffmann

C Garcı́a, B Becerril, B Selisko, M Delepierre… - … and Physiology Part B …, 1997 - Elsevier
A novel crustacean-specific toxin, Cn5, containing 66 amino acid residues was isolated from
the venom of the scorpion Centruroides noxius Hoffmann. It is stabilized by four disulfide …