X-linked hyper-IgM syndrome (XHIM) results from mutations in the gene encoding for CD40
ligand (CD154). Patients with the syndrome suffer from infections with opportunistic …

X-linked hyper-IgM (X-HIM) syndrome is a primary immunodeficiency disease characterized
by defects in both cellular and humoral immunity. X-HIM is caused by mutations in the gene …

X‐linked Hyper‐IgM syndrome (XHIM) is caused by mutations of CD154 gene also known
as CD40 ligand (CD40L). CD40L is expressed in activated T cells and interacts with CD40 …

X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by
genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety …

The X-linked hyper-IgM (XHIGM) syndrome is an uncommon primary immunodeficiency
disease caused by mutations in the gene for CD40 ligand and characterized by normal or …

X-linked hyper IgM syndrome (XHIM), caused by mutations of the CD40 ligand (CD40L)
gene, is characterized by recurrent bacterial and opportunistic infections, an increased …

Background X-linked hyper-IgM (XHIM) is a primary immunodeficiency disorder
characterized by recurrent infections, low serum IgG and IgA and normal or elevated IgM. It …

X‐linked hyper‐IgM syndrome (XHIGM) is one type of primary immunodeficiency diseases,
resulting from defects in the CD40 ligand/CD40 signaling pathways. We retrospectively …

The CD40 ligand expressed on activated T cells plays a pivotal role in B cell proliferation
and differentiation. Mutations in the CD40 ligand gene, which alter its expression on the …

X-linked hyper IgM syndrome is largely caused by defects in the CD40L (CD154). The
patients have low levels of IgG and have difficulty with respiratory infections as well as …