The mesolimbic dopamine (DA) system plays an integral role in incentive motivation and
reward seeking and a growing body of evidence identifies signal transduction at …

Transient increases in nucleus accumbens (NAc) dopamine concentration are observed
when animals are presented with motivationally salient stimuli and are theorized to energize …

Motivational and attentional processes energize action sequences to facilitate evolutionary
competition and promote behavioral fitness. Decades of neuropharmacology …

The ability to discern temporally pertinent environmental events is essential for the
generation of adaptive behavior in conventional tasks, and our overall survival …

Endocannabinoids serve as retrograde signaling molecules at many synapses within the
CNS, particularly GABAergic and glutamatergic synapses. Synapses onto midbrain …

Cannabis sativa, like all known drugs of abuse, leads to increased dopamine activation
within the mesolimbic pathway. Consequent dopamine release within terminal regions of the …

Evidence suggests that the endocannabinoid system has been conserved in the animal
kingdom for 500 million years, and this system influences many critical behavioral processes …

The endocannabinoid system (eCB) is implicated in the mediation of both reward and
reinforcement. This is evidenced by the ability of exogenous cannabinoid drugs to produce …

The nucleus accumbens (NAc) is located in the ventromedial portion of the striatum and is
vital to valence-based predictions and motivated action. The neural architecture of the NAc …

Endogenous cannabinoids play important roles in a variety of functions in the mammalian
brain, including the regulation reward-related information processing. The primary …