Circulating tissue factor accumulates in the developing thrombus and contributes to fibrin
clot formation. To determine whether tissue factor derived from hematopoietic cells is …

Tissue factor (TF) is expressed on nonvascular cells and cells within the vessel wall and
circulates in blood associated with microparticles. Although blood-borne TF accumulates …

Leukocytes and leukocyte-derived microparticles contain low levels of tissue factor (TF) and
incorporate into forming thrombi. Although this circulating pool of TF has been proposed to …

Although it is generally accepted that the initial event in coagulation and intravascular
thrombus formation is the exposure of tissue factor (TF) to blood, there is still little agreement …

Although tissue factor (TF), the principial initiator of physiological coagulation and
pathological thrombosis, has recently been proposed to be present in human blood, the …

Using a laser-induced endothelial injury model, we examined thrombus formation in the
microcirculation of wild-type and genetically altered mice by real-time in vivo microscopy to …

Fibrin can be generated in blood vessels in the absence of substantial damage to the vessel
wall. According to novel observations, fibrin formation within the vessel lumen could be …

Tissue factor (TF) is the cellular receptor for clotting factor VIIa (FVIIa). The formation of TF-
FVIIa complexes on cell surfaces triggers the activation of coagulation cascade and cell …

Thrombus formation following vascular injury is an essential component of both hemostasis
and pathologic vessel occlusion. This process occurs in a closed, pressurized environment …

Exposure of tissue factor (TF)‐bearing cells to blood is the initial event in coagulation and
intravascular thrombus formation. However, the mechanisms which determine thrombus …