Stem cells hold great potential as cell-based therapies to promote vascularization and tissue
regeneration. However, the use of stem cells alone to promote angiogenesis remains limited …

Objective—Human embryonic stem cells (hESCs) offer a sustainable source of endothelial
cells for therapeutic vascularization and tissue engineering, but current techniques for …

Vascular endothelial growth factor (VEGF) is a positive regulator and plays a crucial role in
angiogenesis. We demonstrate that VEGF was highly expressed in cultures of human bone …

Using biodegradable scaffold and a biomimetic perfusion system, our lab has successfully
engineered small-diameter vessel grafts using endothelial cells (ECs) and smooth muscle …

Objective: This study aim to enhance endothelial differentiation of human embryonic stem
cells (hESCs) by transduction of an adenovirus (Ad) vector expressing hVEGF165 gene (Ad …

Numerous clinical trials are utilizing mesenchymal stem cells (MSC) to treat critical limb
ischemia, primarily for their ability to secrete signals that promote revascularization. These …

Bone marrow mesenchymal stem cells (MSCs) have demonstrated their pluripotency to
differentiate into different cell lineages and may be an alternative cell source for vascular …

Various stem cells and their progeny have been used therapeutically for vascular
regeneration. One of the major hurdles for cell-based therapy is low cell retention in vivo …

Biodegradable scaffolds seeded with bone marrow mononuclear cells (BMCs) are the
earliest tissue-engineered vascular grafts (TEVGs) to be used clinically. These TEVGs …

Background—The use of stem and/or progenitor cells to achieve potent vasculogenesis in
humans has been hindered by low cell numbers, implant capacity, and survival. This study …