Intestinal epithelial TBK1 prevents differentiation of T-helper 17 cells and tumorigenesis in mice
Background & Aims Intestinal epithelial cells (IECs) regulate intestinal immune cells,
particularly development of T-helper 17 (Th17) cells. Deregulation of this process leads to …
particularly development of T-helper 17 (Th17) cells. Deregulation of this process leads to …
An intestinal TH17 cell-derived subset can initiate cancer
O Fesneau, V Thevin, V Pinet, C Goldsmith… - Nature …, 2024 - nature.com
Approximately 25% of cancers are preceded by chronic inflammation that occurs at the site
of tumor development. However, whether this multifactorial oncogenic process, which …
of tumor development. However, whether this multifactorial oncogenic process, which …
Myeloid cell TBK1 restricts inflammatory responses
Proinflammatory cytokine production by innate immune cells plays a crucial role in
inflammatory diseases, but the molecular mechanisms controlling the inflammatory …
inflammatory diseases, but the molecular mechanisms controlling the inflammatory …
TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis
The intestine is colonized by hundreds of different species of commensal bacteria, viruses,
and fungi. Therefore, the intestinal immune system is constantly being challenged by foreign …
and fungi. Therefore, the intestinal immune system is constantly being challenged by foreign …
Adoptive transfer of regulatory T cells promotes intestinal tumorigenesis and is associated with decreased NK cells and IL‐22 binding protein
NB Janakiram, A Mohammed, T Bryant… - Molecular …, 2015 - Wiley Online Library
High number of regulatory T cells (Tregs), both circulating and at the tumor site, often
indicates a poor prognosis in CRC patient's possibly impairing natural killer (NK) cell …
indicates a poor prognosis in CRC patient's possibly impairing natural killer (NK) cell …
Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation
K Sugimoto, A Ogawa, Y Shimomura, K Nagahama… - Gastroenterology, 2007 - Elsevier
Background & Aims: Our previous studies have identified a B-cell subset that is induced
under inflammatory conditions in T-cell receptor α knockout (TCRαKO) mice and contributes …
under inflammatory conditions in T-cell receptor α knockout (TCRαKO) mice and contributes …
[HTML][HTML] Wnt/β-catenin signaling in T-cells drives epigenetic imprinting of pro-inflammatory properties and promotes colitis and colon cancer
S Keerthivasan, K Aghajani, M Dose… - Science translational …, 2014 - ncbi.nlm.nih.gov
The density and type of lymphocytes that infiltrate colon tumors are predictive of the clinical
outcome of colon cancer. High densities of TH17 cells and inflammation predict poor …
outcome of colon cancer. High densities of TH17 cells and inflammation predict poor …
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
F Antignano, K Burrows, MR Hughes… - The Journal of …, 2014 - Am Soc Clin Investig
Inflammatory bowel disease (IBD) pathogenesis is associated with dysregulated CD4+ Th
cell responses, with intestinal homeostasis depending on the balance between IL-17 …
cell responses, with intestinal homeostasis depending on the balance between IL-17 …
TANK-binding kinase 1-dependent responses in health and autoimmunity
The pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and systemic
lupus erythematosus (SLE) is driven by genetic predisposition and environmental triggers …
lupus erythematosus (SLE) is driven by genetic predisposition and environmental triggers …
A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features
LP Hale, PK Greer - 2012 - journals.plos.org
Mutations that increase susceptibility to inflammatory bowel disease (IBD) have been
identified in a number of genes in both humans and mice, but the factors that govern how …
identified in a number of genes in both humans and mice, but the factors that govern how …