High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic
colorectal cancers and in most cancers presenting in the inherited condition hereditary …

BACKGROUND Widespread microsatellite instability (MSI) occurs in nearly 15% of sporadic
colorectal cancers. Large bowel carcinomas with high‐frequency MSI (MSI‐H)(instability …

Identification of colorectal carcinomas with high levels of DNA microsatellite instability (MSI-
H) is important because of the suggested prognostic and therapeutic significance associated …

A subset of hereditary and sporadic colorectal carcinomas is defined by microsatellite
instability (MSI), but the spectra of gene mutations have not been characterized extensively …

Molecular analysis of hereditary nonpolyposis colorectal carcinomas (HNPCC) has
identified DNA mismatch repair deficiencies with resulting microsatellite instability (MSI) as a …

Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colorectal cancer and in a large number of …

Microsatellite instability (MSI) is a well-recognized phenomenon that is classically a feature
of tumors in the hereditary non-polyposis colorectal syndrome. Ten to 15% of sporadic …

Alterations of the length of simple repetitive genomic sequences (microsatellite instability,
MSI) characterize a distinct mechanism of colorectal carcinogenesis. Such MSI has been …

Cancer with high levels of microsatellite instability (MSI-H) is the hallmark of hereditary
nonpolyposis colorectal cancer syndrome, and MSI-H occurs in∼ 15% of sporadic …

BACKGROUND AND AIMS In this study, we prospectively examined the clinical significance
of the microsatellite instability (MSI) phenotype in sporadic colorectal cancer, and …