Background—Recent evidence suggests that atrial fibrillation (AF) is maintained by high-
frequency reentrant sources with a left-to-right–dominant frequency gradient, particularly in …

Background—It is unclear whether atrial fibrillation (AF) drivers in humans are focal or
reentrant. To test the hypothesis that functional reentry is involved in human AF …

Subunits of inwardly rectifying potassium channels (Kir) are expressed in many different
tissues of the human body. Inward rectifier currents expressed in the heart are constituted by …

Objectives: The purpose of this study was to compare the voltage-dependent K+ currents of
human cells of the right and left atria and determine whether electrical remodeling produced …

Atrial fibrillation (AF) causes distinct changes in atrial conduction, characterized as electrical
remodeling. Experimental data on the possible significance of alterations of specific K+ …

Chronic atrial fibrillation is associated with a shortening of the atrial action potential duration
and atrial refractory period. To test the hypothesis that these changes are mediated by …

Background Clinical and experimental evidence suggest that the parasympathetic nervous
system is involved in the pathogenesis of atrial fibrillation (AF). However, it is unclear …

Atrial fibrillation (AF) has been linked to increased inward rectifier potassium current, IK1,
either due to AF-induced electrical remodelling, or from functional changes due to the Kir2. 1 …

Background—The molecular mechanism of increased background inward rectifier current (I
K1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active …

Objective: We tested the hypothesis that left atrial (LA) myocytes are more sensitive to
acetylcholine (ACh) than right atrial (RA) myocytes, which results in a greater dose …