FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains
A major challenge in systems neuroscience is to perform precise molecular genetic
analyses of a single neuronal population in the context of the complex mammalian brain …
analyses of a single neuronal population in the context of the complex mammalian brain …
Molecular taxonomy of major neuronal classes in the adult mouse forebrain
Identifying the neuronal cell types that comprise the mammalian forebrain is a central
unsolved problem in neuroscience. Global gene expression profiles offer a potentially …
unsolved problem in neuroscience. Global gene expression profiles offer a potentially …
[HTML][HTML] Genetic dissection of the glutamatergic neuron system in cerebral cortex
Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams
and output channels of the cerebral cortex,, yet all derive from neural progenitors of the …
and output channels of the cerebral cortex,, yet all derive from neural progenitors of the …
Correlated gene expression and target specificity demonstrate excitatory projection neuron diversity
The neocortex contains diverse populations of excitatory neurons segregated by layer and
further definable by their specific cortical and subcortical projection targets. The current …
further definable by their specific cortical and subcortical projection targets. The current …
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
Understanding the cell–cell interactions that control CNS development and function has
long been limited by the lack of methods to cleanly separate neural cell types. Here we …
long been limited by the lack of methods to cleanly separate neural cell types. Here we …
Global transcriptome analysis of genetically identified neurons in the adult cortex
MJ Rossner, J Hirrlinger, SP Wichert… - Journal of …, 2006 - Soc Neuroscience
The enormous cellular complexity of the brain is a major obstacle for gene expression
profiling of neurological disease models, because physiologically relevant changes of …
profiling of neurological disease models, because physiologically relevant changes of …
Molecular and functional definition of the developing human striatum
The complexity of the human brain derives from the intricate interplay of molecular
instructions during development. Here we systematically investigated gene expression …
instructions during development. Here we systematically investigated gene expression …
Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
Nervous systems are composed of various cell types, but the extent of cell type diversity is
poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual …
poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual …
Probing the transcriptome of neuronal cell types
Distinct neuronal cell types acquire and maintain their identity by expressing different genes.
Recently it has become feasible to measure this cell type specific expression by isolating …
Recently it has become feasible to measure this cell type specific expression by isolating …
[HTML][HTML] Extraction of distinct neuronal cell types from within a genetically continuous population
Single-cell transcriptomics of neocortical neurons have revealed more than 100 clusters
corresponding to putative cell types. For inhibitory and subcortical projection neurons …
corresponding to putative cell types. For inhibitory and subcortical projection neurons …