Background Optimal drug treatment for patients with resistant hypertension is undefined. We
aimed to test the hypotheses that resistant hypertension is most often caused by excessive …

Background In the PATHWAY-2 study of resistant hypertension, spironolactone reduced
blood pressure substantially more than conventional antihypertensive drugs. We did three …

Methods We have conducted an open observational study of the use of spironolactone 25–
50 mg in the management of patients with resistant hypertension. This drug was …

The aim of this study is to compare spironolactone versus clonidine as the fourth drug in
patients with resistant hypertension in a multicenter, randomized trial. Medical therapy …

Background The treatment of resistant hypertension (RH) is challenging. Several
observational studies have suggested that the addition of spironolactone to triple-drug …

Objective The efficacy of add-on use of spironolactone in patients with resistant
hypertension has been investigated in several small studies. We performed this meta …

Spironolactone is recommended as fourth-line therapy for essential hypertension despite
few supporting data for this indication. We evaluated the effect among 1411 participants in …

The role of spironolactone in resistant hypertension management is unclear. The aim of this
prospective trial was to evaluate the antihypertensive effect of spironolactone in patients with …

Background Spironolactone is effective at reducing blood pressure in patients with
uncontrolled resistant hypertension. However, the use of spironolactone in patients with …

There is currently limited data on which drug should be used to improve blood pressure (BP)
control in patients with resistant hypertension. This study was designed to assess the effect …