M6P/IGF2 receptor: a candidate breast tumor suppressor gene.
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2r) functions in the
activation of TGFbeta, a potent growth inhibitor for most cell types, the degradation of the …
activation of TGFbeta, a potent growth inhibitor for most cell types, the degradation of the …
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene
AJ Oates, LM Schumaker, SB Jenkins… - Breast cancer research …, 1998 - Springer
Loss of heterozygosity (LOH) at the mannose 6-phosphate/insulin-like growth factor 2
receptor gene locus (M6P/IGF2R) on 6q26-27 has recently been demonstrated in …
receptor gene locus (M6P/IGF2R) on 6q26-27 has recently been demonstrated in …
[PDF][PDF] Genomic structure of the human M6P/IGF2 receptor
JK Killian, RL Jirtle - Mammalian Genome, 1999 - Citeseer
The human mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) gene
located at 6q26 (Rao et al. 1994) encodes for a multifunctional receptor that possesses …
located at 6q26 (Rao et al. 1994) encodes for a multifunctional receptor that possesses …
M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
AT De Souza, GR Hankins, MK Washington, TC Orton… - Nature …, 1995 - nature.com
Abstract The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R)
functions in the intracellular trafficking of lysosomal enzymes1, the activation of the potent …
functions in the intracellular trafficking of lysosomal enzymes1, the activation of the potent …
Deletion of the M6P/IGF2r gene in primary hepatocellular carcinoma
Z Piao, Y Choi, C Park, WJ Lee, JH Park, H Kim - Cancer letters, 1997 - Elsevier
To evaluate the different alteration patterns of the mannose 6-phosphate/insulin-like growth
factor 2 receptor (M6P/IGF2r) gene in hepatocellular carcinoma (HCC), 41 HCCs were …
factor 2 receptor (M6P/IGF2r) gene in hepatocellular carcinoma (HCC), 41 HCCs were …
Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor gene correlates with poor differentiation in early breast carcinomas
Chromosome 6q has been shown to be one of the most frequent sites for allelic loss in
human breast cancer. The mannose 6-phosphate/insulin-like growth factor 2 receptor …
human breast cancer. The mannose 6-phosphate/insulin-like growth factor 2 receptor …
Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors.
AT De Souza, GR Hankins, MK Washington, RL Fine… - Oncogene, 1995 - europepmc.org
The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGFIIr) is required for
the activation of transforming growth factor beta, and previously we have found its …
the activation of transforming growth factor beta, and previously we have found its …
Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis
T Yamada, AT De Souza… - Proceedings of the …, 1997 - National Acad Sciences
This report shows that loss of heterozygosity at the mannose 6-phosphate/insulin-like growth
factor II receptor (M6P/IGF2R) locus occurred in 5/8 (63%) dysplastic liver lesions and 11/18 …
factor II receptor (M6P/IGF2R) locus occurred in 5/8 (63%) dysplastic liver lesions and 11/18 …
Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers
GR Devi, AT De Souza, JC Byrd, RL Jirtle… - Cancer research, 1999 - AACR
Abstract The M6P/IGF2R gene, encoding the insulin-like growth factor II (IGF-II)/mannose 6-
phosphate receptor (IGF2R), is frequently inactivated during carcinogenesis. M6P/IGF2R is …
phosphate receptor (IGF2R), is frequently inactivated during carcinogenesis. M6P/IGF2R is …
Increased expression of the mannose 6‐phosphate/insulin‐like growth factor‐II receptor in breast cancer cells alters tumorigenic properties in vitro and in vivo
JS Lee, J Weiss, JL Martin… - International journal of …, 2003 - Wiley Online Library
Abstract The mannose 6‐phosphate/insulin‐like growth factor‐II receptor (M6P/IGF‐IIR) is
thought to act as a suppressor of tumor growth by binding the mitogenic peptide IGF‐II and …
thought to act as a suppressor of tumor growth by binding the mitogenic peptide IGF‐II and …