Role of the extracytoplasmic‐function σ Factor σH in Mycobacterium tuberculosis global gene expression

R Manganelli, MI Voskuil, GK Schoolnik… - Molecular …, 2002 - Wiley Online Library
Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (σ) factors
encoded in its genome. In previously published work, we and others have shown that …

The Mycobacterium tuberculosis Sigma Factor σB Is Required for Full Response to Cell Envelope Stress and Hypoxia In Vitro, but It Is Dispensable for In Vivo Growth

PA Fontan, MI Voskuil, M Gomez, D Tan… - Journal of …, 2009 - Am Soc Microbiol
The numerous sigma (σ) factors present in Mycobacterium tuberculosis are indicative of the
adaptability of this pathogen to different environmental conditions. In this report, we describe …

The Mycobacterium tuberculosis ECF sigma factor σE: role in global gene expression and survival in macrophages

R Manganelli, MI Voskuil, GK Schoolnik… - Molecular …, 2001 - Wiley Online Library
In previously published work, we identified three Mycobacterium tuberculosis sigma (σ)
factor genes responding to heat shock (sigB, sigE and sigH). Two of them (sigB and sigE) …

Functional Genomics Reveals Extended Roles of the Mycobacterium tuberculosis Stress Response Factor σH

S Mehra, D Kaushal - Journal of bacteriology, 2009 - Am Soc Microbiol
Mycobacterium tuberculosis is one of the most successful pathogens of humankind. During
infection, M. tuberculosis must cope with and survive against a variety of different …

Sigma Factors: Key Molecules in Mycobacterium tuberculosis Physiology and Virulence

R Manganelli - Molecular genetics of mycobacteria, 2014 - Wiley Online Library
Rapid adaptation to changing environments is one of the keys of the success of
microorganisms. Such adaptation is achieved by enabling different strategies, the most …

Evidence of complex transcriptional, translational, and posttranslational regulation of the extracytoplasmic function sigma factor σE in Mycobacterium tuberculosis

V Dona, S Rodrigue, E Dainese, G Palu… - Journal of …, 2008 - Am Soc Microbiol
The extracytoplasmic factor (ECF) sigma factor σE is one of the most studied sigma factors of
Mycobacterium tuberculosis. It has been shown to be involved in virulence as well as in …

Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis

R Manganelli, E Dubnau, S Tyagi… - Molecular …, 1999 - Wiley Online Library
The ability of Mycobacterium tuberculosis to adapt to different environments in the infected
host is essential for its pathogenicity. Consequently, this organism must be able to modulate …

The sigma factors of Mycobacterium tuberculosis: regulation of the regulators

P Sachdeva, R Misra, AK Tyagi, Y Singh - The FEBS journal, 2010 - Wiley Online Library
One of the important determinants of virulence of Mycobacterium tuberculosis is adaptation
to adverse conditions encountered in the host cells. The ability of Mycobacterium to …

The σ factors of Mycobacterium tuberculosis

S Rodrigue, R Provvedi, PE Jacques… - FEMS microbiology …, 2006 - academic.oup.com
Mycobacterium tuberculosis is a remarkable pathogen capable of adapting and surviving in
various harsh conditions. Correct gene expression regulation is essential for the success of …

σ Factors and Global Gene Regulation in Mycobacterium tuberculosis

R Manganelli, R Proveddi, S Rodrigue… - Journal of …, 2004 - Am Soc Microbiol
Tuberculosis remains a worldwide threat despite the availability of the BCG vaccine and
antibiotic treatment. It is estimated that its etiologic agent, Mycobacterium tuberculosis …