Asthma and atopy are related conditions that may share similar genetic susceptibility.
Linkage studies have identified a region on chromosome 5q that contains biologic …

Asthma is a complex inflammatory disorder controlled by both genetic and environmental
influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene …

Allergic airway diseases are associated with skewed TH2 cytokine production, although the
underlying cause of this aberrant immune response is not well understood. Recently, 2 …

Background IL‐18 has been shown to exert anti‐allergic or allergy‐promoting activities, but
the existence of genetic polymorphisms in the coding regions of IL‐18 gene has not been …

Asthma and atopy show epidemiological association and are biologically linked by T-helper
type 2 (Th2) cytokine-driven inflammatory mechanisms. IL-4 operates through the IL-4 …

Background Interleukin (IL)‐13 is an important cytokine secreted from type 2 helper T
lymphocytes. It is essential for modulating IgE synthesis by human B cells. Previous studies …

IL10 is an anti‐inflammatory cytokine that has been found to have lower production in
macrophages and mononuclear cells from asthmatics. Since reduced IL10 levels may …

Background: Asthma and rhinitis may represent two manifestations of the same airway
disease. Genetic research can increase our understanding of their common or distinct …

IL-13 plays a crucial role in the development of allergic asthma by several mechanisms,
including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We …

To cite this article: Beghé B, Hall IP, Parker SG, Moffatt MF, Wardlaw A, Connolly MJ, Fabbri
LM, Ruse C, Sayers I. Polymorphisms in IL13 pathway genes in asthma and chronic …