CRISPR/Cas9: a powerful tool in colorectal cancer research
Y Hu, L Liu, Q Jiang, W Fang, Y Chen, Y Hong… - Journal of Experimental …, 2023 - Springer
Colorectal cancer (CRC) is one of the most common malignant cancers worldwide and
seriously threatens human health. The clustered regulatory interspaced short palindromic …
seriously threatens human health. The clustered regulatory interspaced short palindromic …
[PDF][PDF] Studying cellular and molecular pathways underlying Inflammatory Bowel Disease pathogenesis in humans by CRISPR/Cas9 genetic engineering in human …
LS Frommelt - marshallplan.at
Inflammatory bowel diseases (IBD) represent a heterogenous group of inflammatory and
ulcerative diseases that cause chronic inflammation at various sites in the gastrointestinal …
ulcerative diseases that cause chronic inflammation at various sites in the gastrointestinal …
[HTML][HTML] CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition
JB Post, N Hami, AEE Mertens, S Elfrink, JL Bos… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Anti-EGFR therapy is used to treat metastatic colorectal cancer (CRC) patients, for which
initial response rates of 10–20% have been achieved. Although the presence of HER2 …
initial response rates of 10–20% have been achieved. Although the presence of HER2 …
New Advances in Gastroenterology: The Crucial Role of Molecular Medicine
M Candelli, F Franceschi - International Journal of Molecular Sciences, 2023 - mdpi.com
The significant progress we have recently observed in the field of gastroenterology, both in
the understanding of pathophysiological mechanisms and in the diagnosis and treatment of …
the understanding of pathophysiological mechanisms and in the diagnosis and treatment of …
Abstract PR004: In vitro and in vivo CRISPR screens in colorectal cancer organoids identify suppressors of metastasis
Z Cramer, X Wang, NA Leu, K Monaghan, JH Rhoades… - Cancer Research, 2022 - AACR
Colorectal cancer (CRC) is the 2nd-leading cause of cancer-related deaths worldwide and
metastatic disease remains a major unmet clinical need. Nevertheless, the molecular …
metastatic disease remains a major unmet clinical need. Nevertheless, the molecular …
[HTML][HTML] cAMP stimulates SLC26A3 activity in human colon by a CFTR-dependent mechanism that does not require CFTR activity
CM Tse, J Yin, V Singh, R Sarker, R Lin… - Cellular and molecular …, 2019 - Elsevier
Background & Aims SLC26A3 (DRA) is an electroneutral Cl-/HCO 3-exchanger that is
present in the apical domain of multiple intestinal segments. An area that has continued to …
present in the apical domain of multiple intestinal segments. An area that has continued to …
Colonoscopy-based colorectal cancer modeling in mice with CRISPR–Cas9 genome editing and organoid transplantation
Most genetically engineered mouse models (GEMMs) of colorectal cancer are limited by
tumor formation in the small intestine, a high tumor burden that limits metastasis, and the …
tumor formation in the small intestine, a high tumor burden that limits metastasis, and the …
Microbiota–Liver Diseases Interactions
R Capparelli, P Cuomo, A Gentile… - International Journal of …, 2023 - mdpi.com
Gut microbiota regulates essential processes of host metabolism and physiology: synthesis
of vitamins, digestion of foods non-digestible by the host (such as fibers), and—most …
of vitamins, digestion of foods non-digestible by the host (such as fibers), and—most …