Highlights•Sixteen leading groups review evidence for the therapeutic effects of
agmatine.•Agmatine modulatory action at multiple molecular targets is highlighted.• …

Agmatine, the decarboxylation product of arginine, was largely neglected as an important
player in mammalian metabolism until the mid-1990s, when it was re-discovered as an …

Agmatine, a cationic amine formed by decarboxylation of l-arginine by the mitochondrial
enzyme arginine decarboxylase (ADC), is widely but unevenly distributed in mammalian …

Agmatine is an endogenous neuromodulator that, based on animal studies, has the
potential for new drug development. As an endogenous aminoguanidine compound (1 …

Recent evidence suggests that agmatine, which is an intermediate in polyamine
biosynthesis, might be an important neurotransmitter in mammals. Agmatine is synthesized …

Background: Neurological diseases have always been one of the leading cause of mobility
and mortality world-widely. However, it is still lacking efficient agents. Agmatine, an …

Publisher Summary Current evidence is consistent with a hypothesis that agmatine meets
many criteria for a neurotransmitter-neuromodulator. It is synthesized, stored, and released …

Agmatine, which in other life forms serves as a metabolic intermediate for polyamine
biosynthesis, appears to have properties in mammals consistent with its actions as a …

In acute inflammatory responses, such as wound healing and glomerulonephritis, arginine is
the precursor for production of the cytostatic molecule nitric oxide (NO) and the pro …

Agmatine is a polyamine that is produced via decarboxylation of l-arginine by the enzyme
arginine decarboxylase. It binds to various receptors and has been accepted as a novel …