Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

H Takayanagi - Nature Reviews Immunology, 2007 - nature.com
Osteoimmunology is an interdisciplinary research field focused on the molecular
understanding of the interplay between the immune and skeletal systems. Although …

Osteoimmunology: crosstalk between the immune and bone systems

T Nakashima, H Takayanagi - Journal of clinical immunology, 2009 - Springer
Introduction The interaction between the immune and skeletal systems has long been
acknowledged, but investigation into rheumatoid arthritis (RA) as well as the various bone …

[HTML][HTML] Osteoimmunology: interactions of the immune and skeletal systems

J Rho, M Takami, Y Choi - Molecules and cells, 2004 - Elsevier
Bone is a dynamic tissue that provides mechanical support, physical protection, and enables
movement. Bone also serves as a storage site for minerals and is where blood cells are …

Osteoclasts and the immune system

T Nakashima, H Takayanagi - Journal of bone and mineral metabolism, 2009 - Springer
Investigation into arthritis as well as the numerous bone phenotypes found in mice lacking
immune-related genes has highlighted the importance of the dynamic interplay between the …

New developments in osteoimmunology

H Takayanagi - Nature Reviews Rheumatology, 2012 - nature.com
Investigations into interactions between the skeletal and immune systems were developed
during research into arthritis, with characterization of T-cell-mediated regulation of …

Osteoimmunology: interplay between the immune system and bone metabolism

MC Walsh, N Kim, Y Kadono, J Rho, SY Lee… - Annu. Rev …, 2006 - annualreviews.org
Studies of bone and the immune system have converged in recent years under the banner
of osteoimmunology. The immune system is spawned in the bone marrow reservoir, and …

Osteoimmunology and the effects of the immune system on bone

H Takayanagi - Nature Reviews Rheumatology, 2009 - nature.com
In the pathogenesis of bone destruction associated with rheumatoid arthritis, the synovium is
a site of active interplay between immune and bone cells. The interaction between T cells …

[HTML][HTML] Osteoimmunology: cytokines and the skeletal system

SH Lee, TS Kim, Y Choi, J Lorenzo - BMB reports, 2008 - ncbi.nlm.nih.gov
It has become clear that complex interactions underlie the relationship between the skeletal
and immune systems. This is particularly true for the development of immune cells in the …

New immune connections in osteoclast formation

H Takayanagi - Annals of the New York Academy of Sciences, 2010 - Wiley Online Library
Osteoimmunology is an interdisciplinary research field that investigates the interplay of the
skeletal and immune systems at the molecular level. The interaction between immune cells …

Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

D Jones, LH Glimcher… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Over the past decade and a half, the biomedical community has uncovered a previously
unappreciated reciprocal relationship between cells of the immune and skeletal systems …