Innate immune activation by macrophages is an essential part of host defence against
infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of …

Innate recognition of DNA within intracellular compartments or the cytoplasm leads to
activation of the immune system, which can result in defense against DNA virus infections or …

The detection of intracellular microbial DNA is critical to appropriate innate immune
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …

Interferon-inducible protein (IFI204)(p204, the murine homolog of human IFI16) is known as
a cytosolic DNA sensor to recognize DNA viruses and intracellular bacteria. However, little is …

Many human cells can sense the presence of exogenous DNA during infection though the
cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second …

Interferon γ-inducible protein 16 (IFI16) and cGMP-AMP synthase (cGAS) have both been
proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and …

Deregulated innate immune responses that result in increased levels of type I interferons
(IFNs) and stimulation of IFN-inducible genes are thought to contribute to chronic …

Recent studies have highlighted the importance of immune sensing of cytosolic DNA of both
pathogen and host origin. We aimed to examine the role of DNA sensors interferon-γ …

Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical
for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor …