Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double‐blind randomized controlled trial
TM MacDonald, B Williams, DJ Webb… - Journal of the …, 2017 - Am Heart Assoc
Background Guidelines for hypertension vary in their preference for initial combination
therapy or initial monotherapy, stratified by patient profile; therefore, we compared the …
therapy or initial monotherapy, stratified by patient profile; therefore, we compared the …
Efficacy and safety of a stepped-care regimen using olmesartan medoxomil, amlodipine and hydrochlorothiazide in patients with moderate-to-severe hypertension: an …
M Volpe, C Miele, U Haag - Clinical drug investigation, 2009 - Springer
Background: Treatment guidelines recommend combination therapy to control blood
pressure (BP) in the majority of hypertensive patients. This longterm open-label study …
pressure (BP) in the majority of hypertensive patients. This longterm open-label study …
Combination therapy as initial treatment for newly diagnosed hypertension
JB Byrd, C Zeng, HM Tavel, DJ Magid, PJ O'Connor… - American heart …, 2011 - Elsevier
BACKGROUND: The Seventh Report of the Joint National Committee on Prevention,
Detection, Evaluation, and Treatment of High Blood Pressure recommends that clinicians …
Detection, Evaluation, and Treatment of High Blood Pressure recommends that clinicians …
Is fixed combination therapy appropriate for initial hypertension treatment?
WJ Elliott - Current hypertension reports, 2002 - Springer
Recent clinical trials in hypertension prove how seldom single drug therapy achieves target
blood pressure (BP) and reduces cardiovascular morbidity and mortality. A natural response …
blood pressure (BP) and reduces cardiovascular morbidity and mortality. A natural response …
Combination therapy versus monotherapy as initial treatment for stage 2 hypertension: a prespecified subgroup analysis of a community-based, randomized, open …
Background: Current guidelines suggest consideration of initial combination therapy for
patients with stage 2 hypertension, but rates of hypertension treatment and control in clinical …
patients with stage 2 hypertension, but rates of hypertension treatment and control in clinical …
Triple therapy with olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide in adult patients with hypertension: the TRINITY multicenter, randomized …
S Oparil, M Melino, J Lee, V Fernandez, R Heyrman - Clinical therapeutics, 2010 - Elsevier
Background: Patients with hypertension may require a combination of≥ 2 antihypertensive
agents to achieve blood pressure (BP) control. Objective: The aim of this study was to …
agents to achieve blood pressure (BP) control. Objective: The aim of this study was to …
Strategies for combination therapy in hypertension
AH Gradman - Current opinion in nephrology and hypertension, 2012 - journals.lww.com
Thoughtful use of drug combinations is critical for achieving therapeutic objectives in
hypertensive individuals and populations–more rapid BP control and more effective …
hypertensive individuals and populations–more rapid BP control and more effective …
Initial monotherapy and combination therapy and hypertension control the first year
BM Egan, D Bandyopadhyay, SR Shaftman… - …, 2012 - Am Heart Assoc
Initial antihypertensive therapy with single-pill combinations produced more rapid blood
pressure control than initial monotherapy in clinical trials. Other studies reported better …
pressure control than initial monotherapy in clinical trials. Other studies reported better …
Long‐term efficacy and safety of triple‐combination therapy with olmesartan medoxomil and amlodipine besylate and hydrochlorothiazide for hypertension
DJ Kereiakes, SG Chrysant, JL Izzo Jr… - The Journal of …, 2012 - Wiley Online Library
J Clin Hypertens (Greenwich). 2012; 14: 149–157.© 2012 Wiley Periodicals, Inc. Most
patients with hypertension require combination therapy in order to achieve blood pressure …
patients with hypertension require combination therapy in order to achieve blood pressure …
Tolerability and blood pressure-lowering efficacy of the combination of amlodipine plus valsartan compared with lisinopril plus hydrochlorothiazide in adult patients …
D Poldermans, R Glazes, S Kargiannis, M Wernsing… - Clinical …, 2007 - Elsevier
BACKGROUND:: Most patients with hypertension in the United States and Europe fail to
achieve the recomended target blood pressure (BP) of< 140/90 mm Hg. Combination …
achieve the recomended target blood pressure (BP) of< 140/90 mm Hg. Combination …