Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED birth cohort study

MN Kosek, T Ahmed, Z Bhutta, L Caulfield… - …, 2017 - thelancet.com
Background Environmental enteropathy (EE), the adverse impact of frequent and numerous
enteric infections on the gut resulting in a state of persistent immune activation and altered …

Assessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic framework

M Kosek, RL Guerrant, G Kang, Z Bhutta… - Clinical Infectious …, 2014 - academic.oup.com
Individuals in the developing world live in conditions of intense exposure to enteric
pathogens due to suboptimal water and sanitation. These environmental conditions lead to …

Environmental enteric dysfunction: a review of potential mechanisms, consequences and management strategies

KD Tickell, HE Atlas, JL Walson - BMC medicine, 2019 - Springer
Background Environmental enteric dysfunction (EED) is an acquired enteropathy of the
small intestine, characterized by enteric inflammation, villus blunting and decreased crypt-to …

[HTML][HTML] Dynamics and trends in fecal biomarkers of gut function in children from 1–24 months in the MAL-ED study

BJJ McCormick, GO Lee, JC Seidman… - The American journal …, 2017 - ncbi.nlm.nih.gov
Growth and development shortfalls that are disproportionately prevalent in children living in
poor environmental conditions are postulated to result, at least in part, from abnormal gut …

Environmental enteric dysfunction: an overview

RJ Crane, KDJ Jones… - Food and nutrition …, 2015 - journals.sagepub.com
Background Environmental enteric dysfunction (EED) refers to an incompletely defined
syndrome of inflammation, reduced absorptive capacity, and reduced barrier function in the …

Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response

AA Gilmartin, WA Petri Jr - Philosophical Transactions of …, 2015 - royalsocietypublishing.org
Environmental enteropathy (EE) is a poorly defined state of intestinal inflammation without
overt diarrhoea that occurs in individuals exposed over time to poor sanitation and hygiene …

Assessment of environmental enteric dysfunction in the SHINE trial: methods and challenges

AJ Prendergast, JH Humphrey, K Mutasa… - Clinical infectious …, 2015 - academic.oup.com
Environmental enteric dysfunction (EED) is a virtually ubiquitous, but poorly defined,
disorder of the small intestine among people living in conditions of poverty, which begins …

Environmental enteropathy: elusive but significant subclinical abnormalities in developing countries

K Watanabe, WA Petri - EBioMedicine, 2016 - thelancet.com
Environmental enteropathy/Environmental enteric dysfunction (EE/EED) is a chronic disease
of small intestine characterized by gut inflammation and barrier disruption, malabsorption …

Environmental enteric dysfunction: Gut and microbiota adaptation in pregnancy and infancy

CA Cowardin, S Syed, N Iqbal, Z Jamil… - Nature Reviews …, 2023 - nature.com
Environmental enteric dysfunction (EED) is a subclinical syndrome of intestinal
inflammation, malabsorption and barrier disruption that is highly prevalent in low-and middle …

Environmental enteric dysfunction: pathogenesis, diagnosis, and clinical consequences

GT Keusch, DM Denno, RE Black… - Clinical Infectious …, 2014 - academic.oup.com
Stunting is common in young children in developing countries, and is associated with
increased morbidity, developmental delays, and mortality. Its complex pathogenesis likely …