Under cover: causes, effects and implications of Hsp90‐mediated genetic capacitance
TA Sangster, S Lindquist, C Queitsch - Bioessays, 2004 - Wiley Online Library
The environmentally responsive molecular chaperone Hsp90 assists the maturation of many
key regulatory proteins. An unexpected consequence of this essential biochemical function …
key regulatory proteins. An unexpected consequence of this essential biochemical function …
Protein folding sculpting evolutionary change
S Lindquist - Cold Spring Harbor symposia on quantitative …, 2009 - symposium.cshlp.org
Our work suggests that the forces that govern protein folding exert a profound effect on how
genotypes are translated into phenotypes and that this in turn has strong effects on …
genotypes are translated into phenotypes and that this in turn has strong effects on …
It's not magic–Hsp90 and its effects on genetic and epigenetic variation
RA Zabinsky, GA Mason, C Queitsch… - Seminars in cell & …, 2019 - Elsevier
Canalization, or phenotypic robustness in the face of environmental and genetic
perturbation, is an emergent property of living systems. Although this phenomenon has long …
perturbation, is an emergent property of living systems. Although this phenomenon has long …
Between genotype and phenotype: protein chaperones and evolvability
SL Rutherford - Nature Reviews Genetics, 2003 - nature.com
Protein chaperones direct the folding of polypeptides into functional proteins, facilitate
developmental signalling and, as heat-shock proteins (HSPs), can be indispensable for …
developmental signalling and, as heat-shock proteins (HSPs), can be indispensable for …
Selection transforms the landscape of genetic variation interacting with Hsp90
The protein-folding chaperone Hsp90 has been proposed to buffer the phenotypic effects of
mutations. The potential for Hsp90 and other putative buffers to increase robustness to …
mutations. The potential for Hsp90 and other putative buffers to increase robustness to …
HSP90-buffered genetic variation is common in Arabidopsis thaliana
TA Sangster, N Salathia, HN Lee… - Proceedings of the …, 2008 - National Acad Sciences
HSP90 is a protein chaperone particularly important in the maturation of a diverse set of
proteins that regulate key steps in a multitude of biological processes. Alterations in HSP90 …
proteins that regulate key steps in a multitude of biological processes. Alterations in HSP90 …
HSP90 affects the expression of genetic variation and developmental stability in quantitative traits
TA Sangster, N Salathia, S Undurraga… - Proceedings of the …, 2008 - National Acad Sciences
Modulation of the activity of the molecular chaperone HSP90 has been extensively
discussed as a means to alter phenotype in many traits and organisms. Such changes can …
discussed as a means to alter phenotype in many traits and organisms. Such changes can …
Pervasive contingency and entrenchment in a billion years of Hsp90 evolution
Interactions among mutations within a protein have the potential to make molecular
evolution contingent and irreversible, but the extent to which epistasis actually shaped …
evolution contingent and irreversible, but the extent to which epistasis actually shaped …
The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis
Genetic capacitors moderate expression of heritable variation and provide a novel
mechanism for rapid evolution. The prototypic genetic capacitor, Hsp90, interfaces stress …
mechanism for rapid evolution. The prototypic genetic capacitor, Hsp90, interfaces stress …
Hsp90 and environmental stress transform the adaptive value of natural genetic variation
DF Jarosz, S Lindquist - Science, 2010 - science.org
How can species remain unaltered for long periods yet also undergo rapid diversification?
By linking genetic variation to phenotypic variation via environmental stress, the Hsp90 …
By linking genetic variation to phenotypic variation via environmental stress, the Hsp90 …