Genetic mutations in the leptin pathway can be a cause of human obesity. It is still unknown
whether leptin can be effective in the treatment of fully established morbid obesity and its …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Leptin has emerged over the past decade as a key hormone in not only the regulation of
food intake and energy expenditure but also in the regulation of neuroendocrine and …

Leptin is an adipose tissue hormone that functions as an afferent signal in a negative
feedback loop that maintains homeostatic control of adipose tissue mass. This endocrine …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

THE DISCOVERY of leptin in 1994 has provided a major new piece in the puzzle of obesity.
Leptin is a 167-amino acid peptide made exclusively in adipose tissue. Its absence …

The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and
their reversibility by leptin administration provide compelling evidence for the existence of …

We have previously demonstrated that genetically based leptin deficiency due to a missense
leptin gene mutation in a highly consanguineous extended Turkish pedigree is associated …

The discovery of leptin has provided a robust framework upon which our current
understanding of the mechanisms involved in energy homeostasis has been built. In this …

Leptin is an adipocyte hormone that signals nutritional status to the central nervous system
(CNS) and peripheral organs. Leptin is also synthetized in the placenta and in …