Background—Doxycycline has been shown to effectively inhibit aneurysm formation in
animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix …

BACKGROUND: Matrix metalloproteinase-9 (MMP-9) is thought to play a central role in
abdominal aortic aneurysm (AAA) initiation. Doxycycline, a tetracycline analogue, has direct …

Purpose: Matrix metalloproteinases (MMPs) are considered to play a central role in the
pathogenesis of abdominal aortic aneurysms (AAAs). Doxycycline (Dox) has direct MMP …

Purpose: Abdominal aortic aneurysms are characterized by degradation of the extracellular
matrix, with a reduction in the elastin concentration of the arterial media. These changes are …

Background: Matrix metalloproteinases (MMPs) likely contribute to the degradation of medial
elastin in abdominal aortic aneurysms (AAAs), and tetracycline antibiotics exhibit MMP …

Background: The primary purpose of this study was to evaluate compliance, side effects, and
safety associated with prolonged administration of doxycycline in patients with small …

Background Proteolytic degradation of the aortic wall by matrix metalloproteinases (MMPs)
is considered important in the pathogenesis of abdominal aortic aneurysms (AAAs). Many of …

BACKGROUND: The late durability of endovascular aneurysm repair (EVAR) has been
limited by progressive aortic degeneration believed to be mediated by matrix …

Degradation of the extracellular matrix components elastin and collagen has been
implicated in vascular diseases, including abdominal aortic aneurysm (AAA) and …

Abdominal aortic aneurysm (AAA) is a common disease and a major cause of death through
rupture, the risk of which increases with aneurysm size. There is approximately a 5 year …