The discovery of drivers of cancer has traditionally focused on protein-coding genes,,–. Here
we present analyses of driver point mutations and structural variants in non-coding regions …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in …

Sporadic reports have described cancer cases in which multiple driver mutations (MMs)
occur in the same oncogene,. However, the overall landscape and relevance of MMs remain …

Cancer genomes contain large numbers of somatic mutations but few of these mutations
drive tumor development. Current approaches either identify driver genes on the basis of …

Identification of the genes that cause oncogenesis is a central aim of cancer research. We
searched the proteins predicted from the draft human genome sequence for paralogues of …

Cancer develops through a process of somatic evolution,. Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

The cancer genome is moulded by the dual processes of somatic mutation and selection.
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …

Highly rearranged and mutated cancer genomes present major challenges in the
identification of pathogenetic events driving the neoplastic transformation process. Here we …

Abstract The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis
methods to identify somatic variants across thousands of tumours. Here we present data and …

Genomic information on tumors from 50 cancer types cataloged by the International Cancer
Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently …