Atezolizumab for the treatment of non-small cell lung cancer

FC Santini, CM Rudin - Expert review of clinical pharmacology, 2017 - Taylor & Francis
Introduction: The immune system can restrain or promote cancer development and growth.
Antibodies targeting immune checkpoints have revolutionized cancer treatment. Among the …

Prospects and progress of atezolizumab in non-small cell lung cancer

J Vansteenkiste, E Wauters, K Park… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Immunotherapy has recently come to the forefront of oncology treatment as a
potential means of combating cancer by restoring the body's adaptive cancer-immunity …

New PD-L1 inhibitors in non-small cell lung cancer–impact of atezolizumab

N Seetharamu, IR Preeshagul… - Lung Cancer: Targets …, 2017 - Taylor & Francis
The era of immunotherapy has changed the face of how we approach treatment for many
oncologic and hematologic malignancies. Lung cancer has been in the forefront of …

Product review on the Anti-PD-L1 antibody atezolizumab

NJ Shah, WJ Kelly, SV Liu, K Choquette, A Spira - 2018 - Taylor & Francis
Immunotherapy as a therapeutic strategy has seized the narrative throughout clinical
oncology over the past few years. Once considered a niche treatment for rare cancers …

Atezolizumab: a review in previously treated advanced non-small cell lung cancer

HA Blair - Targeted oncology, 2018 - Springer
Atezolizumab (TECENTRIQ™), an immune checkpoint inhibitor, is an immunoglobulin G1
monoclonal antibody that binds to programmed death ligand 1 (PD-L1) and blocks its …

[HTML][HTML] Safety and clinical activity of atezolizumab monotherapy in metastatic non-small-cell lung cancer: final results from a phase I study

L Horn, SN Gettinger, MS Gordon, RS Herbst… - European Journal of …, 2018 - Elsevier
Introduction Atezolizumab, an anti-programmed death-ligand 1 (PD-L1) antibody, inhibits
PD-L1: PD-1 and PD-L1: B7. 1 interactions, restoring anticancer immunity. Here, we report …

Profile of atezolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives

F Facchinetti, P Bordi, A Leonetti, S Buti… - Drug design …, 2018 - Taylor & Francis
Programed cell death-1/programed death ligand-1 (PD-1/PD-L1) blockade represents an
affirmed reality in the treatment of advanced non-small-cell lung cancer (NSCLC) patients …

[HTML][HTML] Atezolizumab for the first-line treatment of non-small cell lung cancer (NSCLC): current status and future prospects

R Ryu, KE Ward - Frontiers in oncology, 2018 - frontiersin.org
Purpose: Atezolizumab is a programmed death ligand 1 (PDL-1) blocking antibody that was
approved for metastatic non-small cell lung cancer (NSCLC) in patients with disease …

Advances in the treatment of non–small cell lung cancer: focus on nivolumab, pembrolizumab, and atezolizumab

K Leventakos, AS Mansfield - BioDrugs, 2016 - Springer
Immunotherapy is revolutionizing the treatment of non–small cell lung cancer (NSCLC).
Immune checkpoint inhibitors, including programmed cell death protein 1 (PD-1) and …

Atezolizumab: feasible second-line therapy for patients with non-small cell lung cancer? A review of efficacy, safety and place in therapy

F Jean, P Tomasini, F Barlesi - Therapeutic Advances in …, 2017 - journals.sagepub.com
Advanced non-small cell lung cancer (NSCLC) prognosis is still poor and has recently been
reformed by the development of immune checkpoint inhibitors and the approval of anti-PD-1 …