[HTML][HTML] Second-generation antipsychotics and metabolism alterations: a systematic review of the role of the gut microbiome

K Skonieczna-Żydecka, I Łoniewski, A Misera… - …, 2019 - Springer
Rationale Multiple drugs are known to induce metabolic malfunctions, among them second-
generation antipsychotics (SGAs). The pathogenesis of such adverse effects is of …

[HTML][HTML] Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat

KJ Davey, PD Cotter, O O'sullivan, F Crispie… - Translational …, 2013 - nature.com
The atypical antipsychotic olanzapine is often associated with serious metabolic side effects
including weight gain and increased visceral fat. These adverse events are a considerable …

[HTML][HTML] Use of the second-generation antipsychotic, risperidone, and secondary weight gain are associated with an altered gut microbiota in children

SM Bahr, BC Tyler, N Wooldridge, BD Butcher… - Translational …, 2015 - nature.com
The atypical antipsychotic risperidone (RSP) is often associated with weight gain and
cardiometabolic side effects. The mechanisms for these adverse events are poorly …

Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters

KJ Davey, SM O'Mahony, H Schellekens… - …, 2012 - Springer
Abstract Rationale Atypical antipsychotic drugs (AAPDs) such as olanzapine have a serious
side effect profile including weight gain and metabolic dysfunction, and a number of studies …

[HTML][HTML] The effects of antipsychotic medications on microbiome and weight gain in children and adolescents

T Bretler, H Weisberg, O Koren, H Neuman - BMC medicine, 2019 - Springer
Background Atypical antipsychotics, also known as second-generation antipsychotics, are
commonly prescribed as treatment for psychotic disorders in adults, as well as in children …

Antipsychotics-induced metabolic alterations: recounting the mechanistic insights, therapeutic targets and pharmacological alternatives

R Singh, Y Bansal, B Medhi, A Kuhad - European journal of pharmacology, 2019 - Elsevier
Atypical antipsychotics (AAPs) are the drug of choice in the management of mental illnesses
by virtue of their advantage over typical antipsychotics ie least tendency of producing …

[HTML][HTML] Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota

ACC Kao, S Spitzer, DC Anthony, B Lennox… - Translational …, 2018 - nature.com
Olanzapine is an effective antipsychotic drug but since it causes significant weight gain, it is
not well tolerated by psychosis patients. The prebiotic, B-GOS®, attenuates metabolic …

The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain

S Kanji, TM Fonseka, VS Marshe… - European archives of …, 2018 - Springer
With the emergence of knowledge implicating the human gut microbiome in the
development and regulation of several physiological systems, evidence has accumulated to …

[HTML][HTML] The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse

AP Morgan, JJ Crowley, RJ Nonneman… - PloS one, 2014 - journals.plos.org
The second-generation antipsychotic olanzapine is effective in reducing psychotic
symptoms but can cause extreme weight gain in human patients. We investigated the role of …

Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: A scoping review

R Singh, N Stogios, E Smith, J Lee… - Therapeutic …, 2022 - journals.sagepub.com
Schizophrenia (SCZ) is a severe mental disorder with high morbidity and lifetime disability
rates. Patients with SCZ have a higher risk of developing metabolic comorbidities such as …