Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality
and morbidity. The exact cause and mechanism of the progression of AV calcification is …

Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality
and morbidity. Although exact causes and mechanisms of AV calcification are unclear …

Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality
and morbidity. The exact causes and mechanisms of AV calcification are unclear, although …

The aortic valve (AV) achieves unidirectional blood flow between the left ventricle and the
aorta. Although hemodynamic stresses have been shown to regulate valvular biology, the …

The limited durability of xenograft heart valves and the limited supply of allografts have
sparked interest in tissue engineered replacement valves. A bioreactor for tissue engineered …

Hemodynamic stresses are presumed to play an important role in the development of calcific
aortic valve disease (CAVD). The elucidation of the shear stress mechanisms involved in the …

Aortic stenosis caused by valve calcification is a major cause of death around the world.
Hemodynamic factors have been suggested to be major players in the development of valve …

The complex structural organization of the aortic valve (AV) extracellular matrix (ECM)
enables large and highly nonlinear tissue level deformations. The collagen and elastin …

BACKGROUND: The mechanical environment of the aortic valve (AV) has a significant
impact on valve cellular biology and disease progression, but the regional variation in …

Responses of valve endothelial cells (VECs) to shear stresses are important for the
regulation of valve durability. However, the effect of flow patterns subjected to VECs on the …