In the vasculature, ATP-sensitive potassium channels (KATP) channels regulate vascular
tone. Mice with targeted gene disruptions of KATP subunits expressed in vascular smooth …

KATP channels couple the intracellular energy state to membrane excitability and regulate a
wide array of biologic activities. KATP channels contain a pore-forming inwardly rectifying …

Sulfonylurea receptor-containing ATP-sensitive potassium (KATP) channels have been
implicated in cardioprotection, but the cell type and constitution of channels responsible for …

Adenosine triphosphate-sensitive potassium (KATP) channels are thought to mediate the
stress response by sensing intracellular ATP concentration. Cardiomyocyte KATP channels …

The lack of pathological consequences of cardiac ATP-sensitive potassium channel (KATP)
channel gene manipulation is in stark contrast to the effect of similar perturbations in the …

ATP-sensitive potassium (KATP) channels are evolutionarily conserved plasma-membrane
protein complexes, widely represented in tissue beds with high metabolic activity. There …

KATP channels are involved in regulating coronary function, but the contribution of
endothelial KATP channels remains largely uncharacterized. We generated a transgenic …

Physiological and pathophysiological roles of KATP channels have been clarified recently in
genetically engineered mice. The Kir6. 2-containing KATP channels in pancreatic ß-cells …

ATP-sensitive potassium channels (KATP) regulate a range of biological activities by
coupling membrane excitability to the cellular metabolic state. In particular, it has been …

Abstract ATP-sensitive K+(K ATP) channels are present in the sarcolemma of cardiac
myocytes where they link membrane excitability with the cellular bioenergetic state. These …