Biflavonoids as potential small molecule therapeutics for Alzheimer's disease
Flavonoids are naturally occurring phytochemicals found in a variety of fruits and vegetables
and offer color, flavor, aroma, nutritional and health benefits. Flavonoids have been found to …
and offer color, flavor, aroma, nutritional and health benefits. Flavonoids have been found to …
[HTML][HTML] Polyphenolic biflavonoids inhibit amyloid-beta fibrillation and disaggregate preformed amyloid-beta fibrils
EY Choi, SS Kang, SK Lee, BH Han - Biomolecules & therapeutics, 2020 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a devastating neurodegenerative disease and a major cause of
dementia in elderly individuals world-wide. Increased deposition of insoluble amyloid β (Aβ) …
dementia in elderly individuals world-wide. Increased deposition of insoluble amyloid β (Aβ) …
Biflavonoids are superior to monoflavonoids in inhibiting amyloid-β toxicity and fibrillogenesis via accumulation of nontoxic oligomer-like structures
Polymerization of monomeric amyloid-β peptides (Aβ) into soluble oligomers and insoluble
fibrils is one of the major pathways triggering the pathogenesis of Alzheimer's disease (AD) …
fibrils is one of the major pathways triggering the pathogenesis of Alzheimer's disease (AD) …
Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer's disease
Alzheimer's disease is characterized by pathological aggregation of protein tau and amyloid-
β peptides, both of which are considered to be toxic to neurons. Naturally occurring dietary …
β peptides, both of which are considered to be toxic to neurons. Naturally occurring dietary …
Emerging signal regulating potential of small molecule biflavonoids to combat neuropathological insults of Alzheimer's disease
Alzheimer's disease (AD) is a progressive, chronic and severe neurodegenerative disorder
linked with cognitive and memory impairment that eventually lead to death. There are …
linked with cognitive and memory impairment that eventually lead to death. There are …
Flavonoids and Their Glycosides as Anti‐amyloidogenic Compounds: Aβ1–42 Interaction Studies to Gain New Insights into Their Potential for Alzheimer's Disease …
C Guzzi, L Colombo, AD Luigi… - Chemistry–An Asian …, 2017 - Wiley Online Library
Combining NMR spectroscopy, transmission electron microscopy, biochemical and in vitro
toxicity assays, we characterized the effect of flavonoid glycosylation, a chemical …
toxicity assays, we characterized the effect of flavonoid glycosylation, a chemical …
Biflavonoid-induced disruption of hydrogen bonds leads to amyloid-β disaggregation
PK Windsor, SP Plassmeyer, DS Mattock… - International Journal of …, 2021 - mdpi.com
Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer's
disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by …
disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by …
Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues
M Sato, K Murakami, M Uno, Y Nakagawa… - Journal of Biological …, 2013 - ASBMB
The aggregation of the 42-residue amyloid β-protein (Aβ42) is involved in the pathogenesis
of Alzheimer disease (AD). Numerous flavonoids exhibit inhibitory activity against Aβ42 …
of Alzheimer disease (AD). Numerous flavonoids exhibit inhibitory activity against Aβ42 …
Flavonoids for treatment of Alzheimer's disease: An up to date review
JK Kim, SU Park - EXCLI journal, 2021 - excli.de
Flavonoids, an omnipresent class of polyphenolic compounds, are commonly present in
fruits, vegetables, and plant-derived beverages (Panche et al., 2016). To date, more than …
fruits, vegetables, and plant-derived beverages (Panche et al., 2016). To date, more than …
Role of Flavonoids in Management of Various Biological Targets in Alzheimer's Disease: Evidence from Preclinical to Clinical Studies
KS Alharbi, MA Javed Shaikh, SS Imam… - Current Medicinal …, 2023 - ingentaconnect.com
More than 10 million people worldwide have Alzheimer's disease (AD), a degenerative
neurological illness and the most prevalent form of dementia. AD's progression in memory …
neurological illness and the most prevalent form of dementia. AD's progression in memory …