Copper is an essential trace metal for physiological functions, whereas copper overload
causes cytotoxicity in living organisms. Genetically determined systems regulate acquisition …

Abstract Copper transporting ATPase, ATP7A, is an ATP dependent copper pump present in
all vertebrates, critical for the maintenance of intracellular and whole body copper …

Zebrafish (Danio rerio) is a freshwater fish species of Cyprinidae known for its copper (Cu)
intolerance, yet the underlying mechanisms of the sensitivity remain unclear. In this study …

Copper (Cu) is an essential metal, although in excess is highly toxic due to its redox
properties and, therefore intracellular Cu homeostasis is a highly regulated process. Cu …

Copper (Cu) is an essential trace element, playing an important role in lipid metabolism, and
its transporters ATP7A and ATP7B, as Cu-transporting P-type ATPases, are involved in …

We are studying the toxicity of copper to tilapia and zebrafish and have found that the copper
tolerance of tilapia and the sensitivity of zebrafish were due to several proteins' regulation …

Copper is an essential element for normal cellular processes in most eukaryotic organisms,
but is toxic in excessive amounts. Different organisms vary in their ability to tolerate copper …

While Cox17 functions importantly in copper metalation of cytochrome c oxidase and
integral mitochondrial architecture in vertebrates, rare studies have been performed …

Unbalanced copper (Cu) homeostasis is associated with neurological development defects
and diseases. However, the molecular mechanisms remain elusive. Here, central neural …

Copper chaperone for SOD1 (CCS) specifically delivers copper (Cu) to copper, zinc
superoxide dismutase (SOD1) in cytoplasm of mammalian cells. In the present study, small …