Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death
in the United States, with a 95% five-year mortality rate. For over a decade, gemcitabine …

Abstract Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that
removes ubiquitin tags from specific protein substrates in order to alter their degradation rate …

Gemcitabine is the cornerstone of pancreatic cancer treatment. Although effective in most
patients, development of tumor resistance to gemcitabine can critically limit its efficacy. The …

Introduction Ubiquitin-specific protease 7 (USP7) also known as herpesvirus-associated
ubiquitin-specific protease (HAUSP) is a well-characterized cysteine protease that belongs …

Abstract Ubiquitin-specific protease 2 (USP2) belongs to the family of deubiquitinases that
can rescue protein targets from proteasomal degradation by reversing their ubiquitination. In …

Approximately 30% of all breast cancers are caused by a lack of estrogen receptor (ER),
which renders the cancer resistant to endocrine-based therapy. Many studies suggest that …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. With an
overall five-year survival rate remaining below 6%, there is an explicit need to search for …

Abstract Ubiquitin specific peptidase 28 (USP28) is closely associated to the occurrence and
development of various malignancies, and thus has been validated as a promising …

Napabucasin, undergoing multiple clinical trials, was reported to inhibit the signal
transducer and transcription factor 3 (STAT3). To better elucidate its mechanism of action …

The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases.
Cancer genomic analysis identified frequent amplification of USP21 (22%) in human …