Adaptation to cellular stress is not a vital function of normal cells but is required of cancer
cells, and as such might be a sensible target in cancer therapy. Piperlongumine is a …

Piperlongumine (PL), a herbal drug extracted from long pepper (Piper longum L), is known
for its anti-inflammatory and anti-cancer properties. Although, its anti-cancer potential has …

Piperlongumine is a naturally occurring small molecule recently identified to be toxic
selectively to cancer cells in vitro and in vivo. This compound was found to elevate cellular …

Previous research has reported that piperlongumine exerts antitumor properties on several
types of tumor cells. However, its effect on osteosarcoma cells remains unknown. This study …

Piperlongumine (PL) is recently found to kill cancer cells selectively and effectively via
targeting reactive oxygen species (ROS) responses. To further explore the therapeutic …

Piperlongumine (PL), a natural alkaloid from Piper longum L., possesses the highly selective
and effective anticancer property. However, the effect of PL on ovarian cancer cells is still …

Piperlongumine has anti-cancer activity in numerous cancer cell lines via various signaling
pathways. But there has been no study regarding the mechanisms of PL on the lung cancer …

Malignant melanoma is a devastating skin cancer due to its severe drug resistance and
prompt metastasis. Piperlongumine is an anti-inflammation and tumor-suppressing natural …

Piperlongumine (PL) selectively targets a wide spectrum of cancer cells and induces their
death by triggering various pathways, including apoptosis, necrosis and autophagy …

Oral squamous cell carcinoma (OSCC), an aggressive cancer originating in the oral cavity,
is one of the leading causes of cancer deaths in males worldwide. This study investigated …