Due to the usually late diagnosis and lack of effective therapies, hepatocellular carcinoma
(HCC), which poses a growing global health problem, is characterized by a poor prognosis …

Hepatocellular carcinoma (HCC) is a hypervascular malignancy and is the third leading
cause of death worldwide. The disease has multiple predisposing risk factors and limited …

Hepatocellular carcinoma (HCC) is naturally resistant to radiotherapy and cytotoxic
chemotherapy, leaving surgery as the mainstream therapeutic approach. However, the 5 …

Objective To explore the effect of two dominating signaling pathways, VEGF/KDR and
angiopoietins/Tie2, on the formation of new blood vessel in hepatocellular carcinoma (HCC) …

Human hepatocellular carcinoma (HCC) is a hypervascular tumor but the mechanisms
underlying the process of angiogenesis are not fully understood. Angiopoietins (Ang) have …

Aim: Angiopoietin 1 (Ang-1) and its antagonist, angiopoietin 2 (Ang-2), are novel ligands that
regulate the Tie2 receptor. The Ang-2 gene is upregulated in the hypervascular type of …

AIM: To investigate the significance of angiopoietins, Tie2 and vascular endothelial growth
factor (VEGF) expression in the angiogenesis and progress of hepatocellular carcinoma …

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-associated death
worldwide. Angiogenesis, the process of formation of new blood vessels, is required for …

Simple Summary Vessel co-option has been recognized as a mechanism associated with
resistance to anti-angiogenic treatment in colorectal cancer liver metastases (CRCLMs) …

Angiogenesis is a critical step in the development and progression of hepatocellular
carcinoma (HCC). Myeloid lineage cells, such as macrophages and monocytes, have been …