Objective: To assess treatment discontinuation rates with selective serotonin reuptake
inhibitors compared with tricyclic antidepressants. Design: Meta-analysis of 62 randomised …

Objective: To examine inceptions and discontinuations of antidepressants in general
practice. Design: An observational study analysing data from an ongoing cross sectional …

Objective: To compare the efficacy and tolerability of tricyclic antidepressants with selective
serotonin reuptake inhibitors in depression in primary care. Design: Systematic review and …

BACKGROUND: Previous meta-analyses suggest that individuals treated with serotonin-
specific reuptake inhibitors (SSRIs) in randomised controlled trials (RCTs) are less likely to …

OBJECTIVE--To examine the evidence for using selective serotonin reuptake inhibitors
instead of tricyclic antidepressants in the first line treatment of depression. DESIGN--Meta …

The present study aimed to systematically compare overall loss to follow-up, discontinuation
rates because of adverse events and discontinuation rates because of a lack of efficacy in …

Did regulators fail over selective serotonin reuptake inhibitors? | The BMJ Skip to main content
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BACKGROUND: The use of antidepressant medications and the resulting costs have
increased dramatically in recent years, partly because of the introduction of selective …

Objective: To evaluate a policy to reduce the incidence of suicide by means of changing the
prescribing of antidepressants from the older tricyclic antidepressants to the routine first line …

BackgroundPatients with depression are often not prescribed antidepressants for an
adequate period of time. AimsThe impact of antidepressant prescribing patterns on the risk …