Three members of an Italian family with autosomal dominant dementia and multiple strokes
had the A713T mutation of the APP gene. The neuropathologic examination of the proband …

Objective: To report, for the first time, a large autosomal dominant Alzheimer disease (AD)
family in which the APP A713T mutation is present in the homozygous and heterozygous …

The occurrence of an APP T174I mutation is described in a large American family of African
descent with Alzheimer disease. The clinical characteristics were an unusually early onset of …

We present prospective clinical and neuropathologic details of a pedigree segregating
familial Alzheimer's disease (FAD) associated with a mutation (G→ A substitution) at …

An Iranian family with Alzheimer’s disease caused by a novel APP mutation (Thr714Ala) |
Neurology Skip to main content Skip to main content AAN.com AAN Publications Author Center …

We found a novel polymorphism in the amyloid precursor protein (APP) gene in a patient
with ischemic cerebrovascular disease who had no evidence of Alzheimer's disease (AD) …

Abstract Mutations at codons 717 and 670/671 in the amyloid precursor protein (APP) are
rare genetic causes of familial Alzheimer's disease (AD). A mutation at codon 693 of APP …

Several families with an early–onset form of familial Alzheimer's disease have been found to
harbour mutations at a specific codon (717) of the gene for the β–amyloid precursor protein …

Early onset Familial Alzheimer's Disease (FAD) is an autosomal dominant disease with
apparent complete penetrance. It is genetically heterogeneous with some families carrying …

Background and Objectives This study reports an uncommon case of autosomal dominant
Alzheimer disease (AD) with negative PiB-PET findings. Methods A 55-year-old woman was …