Introduction SOD1 was the first gene associated with both familial and sporadic forms of
amyotrophic lateral sclerosis (ALS) and is the second most mutated gene in Caucasian ALS …

Background Uncovering distinct features and trajectories of amyotrophic lateral sclerosis
(ALS) associated with SOD1 mutations (SOD1-ALS) can provide valuable insights for …

Amyotrophic lateral sclerosis (ALS) is the most common type of motor neuron disease
whose causes are unclear. The first ALS gene associated with the autosomal dominant form …

Background SOD1 mutations are the most common cause of amyotrophic lateral sclerosis
(ALS) in non-Caucasian patients. Detailed natural history profiles of SOD1-mutant patients …

Background: Mutations in superoxide dismutase 1 gene (SOD1) are the most frequent high
penetrant genetic cause for amyotrophic lateral sclerosis (ALS) in the Chinese population. A …

Abstract Amyotrophic Lateral Sclerosis (ALS), the most common form among motoneuron
diseases, is characterized by a progressive neurodegenerative process involving motor …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease in adults of unknown
origin in most cases. Here we report a novel P66S mutation in exon 3 of the SOD1 gene in …

Background and objectives Amyotrophic lateral sclerosis associated with mutations in SOD1
(SOD1-ALS) might be susceptible to specific treatment. The aim of the study is to outline the …

Objective Mutations in superoxide dismutase 1 gene (SOD1), encoding copper/zinc
superoxide dismutase protein, are the second most frequent high penetrant genetic cause …

Purpose Familial amyotrophic lateral sclerosis has been linked to mutations in 15 genes,
and it is believed these genes account for less than 20–30% of Chinese patients with …