Short tandem repeats (STRs) are hypervariable genetic elements that occur frequently in
coding regions. Their high mutation rate readily generates genetic variation, contributing to …

Tandem repeats (TRs) have extremely high mutation rates and are often considered to be
neutrally evolving DNA. However, in coding regions, TR copy number mutations can …

Short tandem repeat (STR) mutations may comprise more than half of the mutations in
eukaryotic coding DNA, yet STR variation is rarely examined as a contributor to complex …

The genetic basis for the fine-tuned regulation of gene expression is complex and ultimately
influences the phenotype and thus the local adaptation of natural populations. Short tandem …

Studying the genetic regulation of expression variation is a key method to dissect complex
phenotypic traits. To examine the genetic architecture of regulatory variation in Arabidopsis …

Variation in regulatory DNA is thought to drive phenotypic variation, evolution, and disease.
Prior studies of regulatory DNA and transcription factors across animal species highlighted a …

The phenotypic effect of a gene is normally described by the mean-difference between
alternative genotypes. A gene may, however, also influence the phenotype by causing a …

Triplet repeat expansions underlie several human genetic diseases such as Huntington's
disease and Friedreich's ataxia. Although such mutations are primarily known from humans …

Efforts to identify loci underlying complex traits generally assume that most genetic variance
is additive. Here, we examined the genetics of Arabidopsis thaliana root length and found …

The advances of high-throughput sequencing offer an unprecedented opportunity to study
genetic variation. This is challenged by the difficulty of resolving variant calls in repetitive …