Background COX-2 is an enzyme isoform that catalyses the formation of prostanoids from
arachidonic acid. An increased COX-2 gene expression is believed to participate in …

Abstract Background Cyclooxygenase-2 (COX-2) seems to play a role in the development
and carcinogenesis of papillary thyroid carcinoma. Its incidence of expression and potential …

Background: Recent evidence indicates that elevated COX-2 expression is associated with
the carcinogenesis of numerous neoplasms. In this study, we investigated COX-2 …

Abstract Objectives: Cyclooxygenase (COX)-2, which is the inducible form of the COX
enzyme for prostaglandin synthesis and a key mediator of epithelial cell growth, has been …

Introduction The cyclooxygenases are a group of enzymes catalyzing the formation of
prostaglandins from arachidonic acid. Cyclooxygenase-1 (COX-1) is a constitutive form …

Factors contributing to the development of thyroid neoplasia remain poorly understood.
Recent evidence indicates that overexpression of the inducible cyclooxygenase, COX-2, is …

Cyclooxygenase (COX), also known as prostaglandin H synthase, catalyses the formation of
prostaglandins from arachidonic acid. It can be expressed in response to various stimuli …

BACKGROUND: Thyroid carcinoma is one of the most common malignancies worldwide.
More than 70%-80% are papillary thyroid carcinoma (PTC). Many factors influence the PTC …

Aims: To study cyclooxygenase‐2 (COX‐2) and matrix metalloproteinase‐2 (MMP‐2)
expression in papillary thyroid cancer (PTC). Expression of COX‐2 is elevated in various …

Both anaplastic thyroid carcinoma (ATC) and angiosarcoma of the thyroid (AST) are highly
aggressive malignancies with very limited therapeutic options. Since selective inhibition of …