Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a
hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset …

Metabolic reprogramming of cancer cells generates a tumour microenvironment (TME)
characterised by nutrient restriction, hypoxia, acidity and oxidative stress. While these …

Recent studies have shown that on one hand, tumors need to obtain a sufficient energy
supply, and on the other hand they must evade the body's immune surveillance. Because of …

Characterized by the expression of the critical transcription factor forkhead box protein P3,
regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the …

In the last decades, immunologists have started to consider intracellular metabolism in
relation with the dynamics and functions of immune cells, especially when it became clear …

The occurrence and development of tumors require the metabolic reprogramming of cancer
cells, namely the alteration of flux in an autonomous manner via various metabolic pathways …

Cellular metabolism is not only essential for tumor cells to sustain their rapid growth and
proliferation, but also crucial to maintain T cell fitness and robust immunity. Dysregulated …

Although targeting the tumor metabolism is performed in cooperation with immunotherapy in
the era of precision oncology, ignorance of immune cells' metabolism has resulted in …

Although immunotherapy has achieved good results in various cancer types, a large
proportion of patients are limited from the benefits. Hypoxia and metabolic reprogramming …

Immune editing orchestrates the tumor initiation and progression. The crosstalk between
tumor cells and immune cells in the tumor microenvironment (TME) manipulates the …